MAP2K2

MAP2K2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1S9I, 4H3Q
Dynodwyr
Cyfenwau	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2, mitogen-activated protein kinase kinase 2
Dynodwyr allanol	OMIM: 601263 HomoloGene: 48591 GeneCards: MAP2K2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • PDZ domain binding • scaffold protein binding • protein serine/threonine kinase activator activity • metal ion binding • kinase activity • GO:0001948, GO:0016582 protein binding • protein serine/threonine/tyrosine kinase activity • protein tyrosine kinase activity • ATP binding • MAP kinase kinase activity • protein serine/threonine kinase activity Cydrannau o'r gell • late endosome • Golgi apparatus • bilen • focal adhesion • cell-cell junction • peroxisomal membrane • extracellular region • early endosome • Reticwlwm endoplasmig • mitocondria • perinuclear region of cytoplasm • cytoplasmic side of plasma membrane • microtubule • cnewyllyn cell • cytoplasm • cytosol • Cellbilen Prosesau biolegol • phosphorylation • regulation of early endosome to late endosome transport • peptidyl-serine autophosphorylation • negative regulation of gene expression • positive regulation of protein serine/threonine kinase activity • protein phosphorylation • peptidyl-tyrosine phosphorylation • regulation of Golgi inheritance • regulation of stress-activated MAPK cascade • MAPK cascade • ERK1 and ERK2 cascade • positive regulation of production of miRNAs involved in gene silencing by miRNA • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of ERK1 and ERK2 cascade • regulation of mitotic cell cycle • regulation of apoptotic process • GO:0072468 signal transduction • stress-activated protein kinase signaling cascade • activation of protein kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5605	n/a
Ensembl	ENSG00000126934	n/a
UniProt	P36507	n/a
RefSeq (mRNA)	NM_030662	n/a
RefSeq (protein)	NP_109587	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP2K2 yw MAP2K2 a elwir hefyd yn Mitogen-activated protein kinase kinase 2, isoform CRA_d a Mitogen-activated protein kinase kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP2K2.

• CFC4
• MEK2
• MKK2
• MAPKK2
• PRKMK2

Llyfryddiaeth

• "Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?". Clin Genet. 2014. PMID 23379592.
• "A full-length 3D structure for MAPK/ERK kinase 2 (MEK2). ". Sci China Life Sci. 2011. PMID 21509657.
• "Concurrent occurrence of an inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving MAP2K2 in a patient with developmental delay, distinctive facial features, and lambdoid synostosis. ". Eur J Med Genet. 2016. PMID 27751966.
• "Familial cardiofaciocutaneous syndrome in a father and a son with a novel MEK2 mutation. ". Am J Med Genet A. 2015. PMID 25487361.
• "Multiple café au lait spots in familial patients with MAP2K2 mutation.". Am J Med Genet A. 2014. PMID 24311457.