MAP1LC3B

MAP1LC3B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN
Dynodwyr
Cyfenwau	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
Dynodwyr allanol	OMIM: 609604 HomoloGene: 69359 GeneCards: MAP1LC3B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • ubiquitin protein ligase binding • microtubule binding Cydrannau o'r gell • cytoplasm • organelle membrane • bilen • intracellular anatomical structure • mitocondria • GO:0035085 axoneme • microtubule • Cytosgerbwd • GO:0016023 cytoplasmic vesicle • endomembrane system • autophagosome membrane • cytosol • autophagosome • autolysosome Prosesau biolegol • autophagy of mitochondrion • autophagosome assembly • autophagy • cellular response to nitrogen starvation • cellular response to starvation • macroautophagy • GO:0000046 autophagosome maturation • positive regulation of mucus secretion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	81631	n/a
Ensembl	ENSG00000140941	n/a
UniProt	Q9GZQ8	n/a
RefSeq (mRNA)	NM_022818	n/a
RefSeq (protein)	NP_073729	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAP1LC3B yw MAP1LC3B a elwir hefyd yn Microtubule-associated protein 1 light chain 3 beta, isoform CRA_f a Microtubule associated protein 1 light chain 3 beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16q24.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAP1LC3B.

• LC3B
• ATG8F
• MAP1LC3B-a
• MAP1A/1BLC3

Llyfryddiaeth

• "Autophagy is upregulated during colorectal carcinogenesis, and in DNA microsatellite stable carcinomas. ". Oncol Rep. 2015. PMID 26502823.
• "Inhibition of microtubule-associated protein 1 light chain 3B via small-interfering RNA or 3-methyladenine impairs hypoxia-induced HO8910PM and HO8910 epithelial ovarian cancer cell migration and invasion and is associated with RhoA and alterations of the actin cytoskeleton. ". Oncol Rep. 2015. PMID 25607473.
• "A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ. ". Biochem Biophys Res Commun. 2017. PMID 28668392.
• "Specific localization of LC3B in autophagosome: A correlative labelling study with nanoparticle in oral squamous cell carcinoma. ". Exp Mol Pathol. 2017. PMID 28506764.
• "The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane.". Autophagy. 2017. PMID 27791457.