MAN1B1

MAN1B1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FMI, 1FO2, 1FO3, 1X9D
Dynodwyr
Cyfenwau	MAN1B1, ERMAN1, MANA-ER, MRT15, ERManI, mannosidase alpha class 1B member 1
Dynodwyr allanol	OMIM: 604346 HomoloGene: 5230 GeneCards: MAN1B1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • calcium ion binding • hydrolase activity, acting on glycosyl bonds • hydrolase activity • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • catalytic activity Cydrannau o'r gell • extracellular vesicle • integral component of membrane • Golgi apparatus • bilen • endoplasmic reticulum membrane • Reticwlwm endoplasmig • endoplasmic reticulum quality control compartment • Golgi membrane Prosesau biolegol • oligosaccharide metabolic process • metabolaeth • N-glycan processing • mannose trimming involved in glycoprotein ERAD pathway • protein alpha-1,2-demannosylation • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • ubiquitin-dependent ERAD pathway • trimming of terminal mannose on B branch • trimming of terminal mannose on C branch • trimming of first mannose on A branch • trimming of second mannose on A branch • endoplasmic reticulum mannose trimming Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	11253	n/a
Ensembl	ENSG00000177239	n/a
UniProt	Q9UKM7	n/a
RefSeq (mRNA)	NM_016219	n/a
RefSeq (protein)	NP_057303	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAN1B1 yw MAN1B1 a elwir hefyd yn Mannosidase alpha class 1B member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAN1B1.

• MRT15
• ERMAN1
• ERManI
• MANA-ER

Llyfryddiaeth

• "MAN1B1 deficiency: an unexpected CDG-II. ". PLoS Genet. 2013. PMID 24348268.
• "ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC). ". PLoS One. 2013. PMID 23940818.
• "Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates. ". Mol Biol Cell. 2015. PMID 25411339.
• "Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency. ". Brain. 2014. PMID 24566669.
• "Trimming of glucosylated N-glycans by human ER α1,2-mannosidase I.". J Biochem. 2014. PMID 24519966.