MAN1A1

MAN1A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NXC
Dynodwyr
Cyfenwau	MAN1A1, HUMM3, HUMM9, MAN9, mannosidase alpha class 1A member 1
Dynodwyr allanol	OMIM: 604344 HomoloGene: 4316 GeneCards: MAN1A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • hydrolase activity • mannosidase activity • hydrolase activity, acting on glycosyl bonds • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity • catalytic activity Cydrannau o'r gell • integral component of membrane • Golgi membrane • Golgi apparatus • extracellular exosome • Reticwlwm endoplasmig • bilen • endoplasmic reticulum-Golgi intermediate compartment • cytosol Prosesau biolegol • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation • N-glycan processing • metabolaeth • Golgi apparatus mannose trimming Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4121	n/a
Ensembl	ENSG00000111885	n/a
UniProt	P33908	n/a
RefSeq (mRNA)	NM_005907	n/a
RefSeq (protein)	NP_005898	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAN1A1 yw MAN1A1 a elwir hefyd yn Mannosidase alpha class 1A member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6q22.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAN1A1.

• MAN9
• HUMM3
• HUMM9

Llyfryddiaeth

• "The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I. ". J Cell Sci. 2009. PMID 19258393.
• "Man9-mannosidase from human kidney is expressed in COS cells as a Golgi-resident type II transmembrane N-glycoprotein. ". Eur J Biochem. 1995. PMID 7588811.
• "Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells. ". J Immunother. 2011. PMID 21577142.
• "Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis. ". J Biol Chem. 1999. PMID 10409699.
• "Man9-mannosidase from pig liver is a type-II membrane protein that resides in the endoplasmic reticulum. cDNA cloning and expression of the enzyme in COS 1 cells.". Eur J Biochem. 1997. PMID 9219526.