MAGI2

MAGI2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1UEP, 1UEQ, 1UEW, 1UJV, 1WFV
Dynodwyr
Cyfenwau	MAGI2, ACVRIP1, AIP-1, AIP1, ARIP1, MAGI-2, SSCAM, membrane associated guanylate kinase, WW and PDZ domain containing 2, NPHS15
Dynodwyr allanol	OMIM: 606382 HomoloGene: 8189 GeneCards: MAGI2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signal transducer activity • SMAD binding • phosphatase binding • beta-1 adrenergic receptor binding • GO:0032947 molecular adaptor activity • type II activin receptor binding • signaling receptor complex adaptor activity • GO:0001948, GO:0016582 protein binding • activin receptor binding • kinase activity Cydrannau o'r gell • late endosome • cytoplasm • synapse • cell junction • cnewyllyn cell • neuron projection • GO:0097483, GO:0097481 postsynaptic density • bilen • dendrite • perinuclear region of cytoplasm • slit diaphragm • bicellular tight junction • Cellbilen • endosome • GO:0009327 protein-containing complex • cell-cell junction Prosesau biolegol • receptor clustering • negative regulation of cell population proliferation • positive regulation of neuron projection development • neuroligin clustering involved in postsynaptic membrane assembly • GO:0072468 signal transduction • negative regulation of activin receptor signaling pathway • nerve growth factor signaling pathway • planar cell polarity pathway involved in axis elongation • SMAD protein signal transduction • positive regulation of receptor internalization • protein heterooligomerization • negative regulation of protein kinase B signaling • nervous system development • glomerular visceral epithelial cell development • positive regulation of synaptic vesicle clustering • cellular response to nerve growth factor stimulus • positive regulation of phosphoprotein phosphatase activity • negative regulation of cell migration • positive regulation of signal transduction • phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9863	n/a
Ensembl	ENSG00000187391	n/a
UniProt	Q86UL8	n/a
RefSeq (mRNA)	NM_001301128 NM_012301	n/a
RefSeq (protein)	NP_001288057 NP_036433	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MAGI2 yw MAGI2 a elwir hefyd yn Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 a Membrane associated guanylate kinase, WW and PDZ domain containing 2, isoform CRA_c (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7q21.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MAGI2.

• AIP1
• AIP-1
• ARIP1
• SSCAM
• MAGI-2
• ACVRIP1

Llyfryddiaeth

• "Expression profile of MAGI2 gene as a novel biomarker in combination with major deregulated genes in prostate cancer. ". Mol Biol Rep. 2014. PMID 24985972.
• "Common variants in MAGI2 gene are associated with increased risk for cognitive impairment in schizophrenic patients. ". PLoS One. 2012. PMID 22649501.
• "MAGI2Mutations Cause Congenital Nephrotic Syndrome. ". J Am Soc Nephrol. 2017. PMID 27932480.
• "MAGI-2 Is a Sensitive and Specific Marker of Prostatic Adenocarcinoma:  A Comparison With AMACR. ". Am J Clin Pathol. 2016. PMID 27543977.
• "MAGI-2 in prostate cancer: an immunohistochemical study.". Hum Pathol. 2016. PMID 26980016.