LRPAP1

LRPAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1LRE, 1NRE, 1OP1, 1OV2, 2FCW, 2FTU, 2FYL, 2P01, 2P03
Dynodwyr
Cyfenwau	LRPAP1, A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP, LDL-receptor-related protein associated protein, LDL receptor related protein associated protein 1
Dynodwyr allanol	OMIM: 104225 HomoloGene: 37612 GeneCards: LRPAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • lipase binding • very-low-density lipoprotein particle receptor binding • low-density lipoprotein particle receptor binding • GO:0001948, GO:0016582 protein binding • signaling receptor binding • heparin binding • receptor antagonist activity • amyloid-beta binding Cydrannau o'r gell • cytoplasm • fesigl • cell surface • Reticwlwm endoplasmig • rough endoplasmic reticulum • extracellular region • endosome • endoplasmic reticulum-Golgi intermediate compartment • Golgi apparatus • Golgi lumen • cis-Golgi network • Cellbilen • endosome lumen • rough endoplasmic reticulum lumen Prosesau biolegol • negative regulation of protein binding • negative regulation of very-low-density lipoprotein particle clearance • negative regulation of amyloid-beta clearance • regulation of receptor-mediated endocytosis • extracellular negative regulation of signal transduction • negative regulation of receptor internalization • negative regulation of cell death • amyloid-beta clearance by transcytosis • positive regulation of amyloid-beta clearance • negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4043	n/a
Ensembl	ENSG00000163956	n/a
UniProt	P30533	n/a
RefSeq (mRNA)	NM_002337	n/a
RefSeq (protein)	NP_002328	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LRPAP1 yw LRPAP1 a elwir hefyd yn LDL receptor related protein associated protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4p16.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LRPAP1.

• RAP
• MRAP
• A2RAP
• HBP44
• MYP23
• A2MRAP
• alpha-2-MRAP

Llyfryddiaeth

• "Clinical Characterization of LRPAP1-Related Pediatric High Myopia. ". Ophthalmology. 2016. PMID 26271838.
• "Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells. ". PLoS One. 2013. PMID 23894629.
• "Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein. ". J Neurochem. 2010. PMID 20002523.
• "Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. ". J Endocrinol Invest. 2007. PMID 18075286.
• "Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility.". Int J Gastrointest Cancer. 2006. PMID 17987404.