LPXN

LPXN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X3H, 4XEF, 4XEK, 4XEV
Dynodwyr
Cyfenwau	LPXN, LDPL, leupaxin
Dynodwyr allanol	OMIM: 605390 HomoloGene: 3536 GeneCards: LPXN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • GO:0001104 transcription coregulator activity • metal ion binding Cydrannau o'r gell • cytoplasm • perinuclear region of cytoplasm • podosome • cell junction • Cellbilen • cell projection • cnewyllyn cell • focal adhesion • bilen • cytosol • nuclear speck Prosesau biolegol • negative regulation of B cell receptor signaling pathway • negative regulation of cell adhesion • cell adhesion • regulation of cell adhesion mediated by integrin • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0072468 signal transduction • GO:0034622 protein-containing complex assembly • regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9404	n/a
Ensembl	ENSG00000110031	n/a
UniProt	O60711	n/a
RefSeq (mRNA)	NM_001143995 NM_001307951 NM_004811	n/a
RefSeq (protein)	NP_001137467 NP_001294880 NP_004802	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LPXN yw LPXN a elwir hefyd yn Leupaxin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LPXN.

• LDPL

Llyfryddiaeth

• "Structural Basis for the Interaction between Pyk2-FAT Domain and Leupaxin LD Repeats. ". Biochemistry. 2016. PMID 26866573.
• "Regulation of β-catenin transcription activity by leupaxin in hepatocellular carcinoma. ". Tumour Biol. 2016. PMID 26361959.
• "Leupaxin stimulates adhesion and migration of prostate cancer cells through modulation of the phosphorylation status of the actin-binding protein caldesmon. ". Oncotarget. 2015. PMID 26079947.
• "Leupaxin is expressed in mammary carcinoma and acts as a transcriptional activator of the estrogen receptor α. ". Int J Oncol. 2015. PMID 25955236.
• "LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation.". Genes Chromosomes Cancer. 2009. PMID 19760607.