LIN28A

LIN28A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2CQF, 2LI8
Dynodwyr
Cyfenwau	LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A
Dynodwyr allanol	OMIM: 611043 HomoloGene: 32592 GeneCards: LIN28A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • zinc ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • RNA binding • nucleic acid binding • translation initiation factor binding • mRNA binding • G-quadruplex RNA binding • miRNA binding • sequence-specific mRNA binding • polysome binding Cydrannau o'r gell • cytoplasm • cytosol • nucleolus • cnewyllyn cell • Reticwlwm endoplasmig • rough endoplasmic reticulum • polysome • P-body • cytoplasmic stress granule • ribonucleoprotein complex Prosesau biolegol • GO:1905616 regulation of gene silencing by miRNA • germ cell development • miRNA catabolic process • GO:0009373 regulation of transcription, DNA-templated • RNA 3'-end processing • somatic stem cell population maintenance • negative regulation of glial cell differentiation • positive regulation of translation • stem cell differentiation • positive regulation of cell proliferation involved in kidney development • stem cell population maintenance • pre-miRNA processing • positive regulation of neuron differentiation • GO:0061715 miRNA metabolic process • gene silencing • negative regulation of translation • positive regulation of TOR signaling • positive regulation of protein kinase B signaling • cellular response to glucose stimulus • positive regulation of production of miRNAs involved in gene silencing by miRNA • positive regulation of cytoplasmic translation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	79727	n/a
Ensembl	ENSG00000131914	n/a
UniProt	Q9H9Z2	n/a
RefSeq (mRNA)	NM_024674	n/a
RefSeq (protein)	NP_078950	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIN28A yw LIN28A a elwir hefyd yn Lin-28 homolog A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p36.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIN28A.

• CSDD1
• LIN28
• LIN-28
• ZCCHC1
• lin-28A

Llyfryddiaeth

• "Lin28 induces resistance to anti-androgens via promotion of AR splice variant generation. ". Prostate. 2016. PMID 26714839.
• "Lin28A enhances chemosensitivity of colon cancer cells to 5-FU by promoting apoptosis in a let-7 independent manner. ". Tumour Biol. 2016. PMID 26687759.
• "Lin28a enhances in vitro osteoblastic differentiation of human periosteum-derived cells. ". Cell Biochem Funct. 2017. PMID 29143345.
• "Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. ". Stem Cell Res Ther. 2016. PMID 27230676.
• "RNA-binding protein Lin28 in cancer and immunity.". Cancer Lett. 2016. PMID 26945970.