LIMK2

LIMK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X6A, 4TPT
Dynodwyr
Cyfenwau	LIMK2, LIM domain kinase 2
Dynodwyr allanol	OMIM: 601988 HomoloGene: 55911 GeneCards: LIMK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein serine/threonine kinase activity • ATP binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • nucleotide binding • kinase activity • metal ion binding • protein kinase activity • transferase activity • signal transducer activity Cydrannau o'r gell • cnewyllyn cell • cytoplasm • cis-Golgi network Prosesau biolegol • protein phosphorylation • spermatogenesis • phosphorylation • GO:0007243 intracellular signal transduction • head development • cornea development in camera-type eye • actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3985	n/a
Ensembl	ENSG00000182541	n/a
UniProt	P53671	n/a
RefSeq (mRNA)	NM_016733 NM_001031801 NM_005569	n/a
RefSeq (protein)	NP_001026971 NP_005560 NP_057952	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIMK2 yw LIMK2 a elwir hefyd yn LIM domain kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q12.2.

Llyfryddiaeth

• "LIMK2 mediates resistance to chemotherapeutic drugs in neuroblastoma cells through regulation of drug-induced cell cycle arrest. ". PLoS One. 2013. PMID 23991158.
• "Phosphorylation-dependent regulation of unique nuclear and nucleolar localization signals of LIM kinase 2 in endothelial cells. ". J Biol Chem. 2006. PMID 16820362.
• "Cloning and characterization of the alternative promoter regions of the human LIMK2 gene responsible for alternative transcripts with tissue-specific expression. ". Gene. 1999. PMID 10452946.
• "Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation. ". Biochem Biophys Res Commun. 1996. PMID 8954941.
• "Whole Exome Sequencing Identifies Rare Protein-Coding Variants in Behçet's Disease.". Arthritis Rheumatol. 2016. PMID 26662719.