LIG4

LIG4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IK9, 2E2W, 3II6, 3VNN, 3W1B, 3W1G, 3W5O, 4HTO, 4HTP
Dynodwyr
Cyfenwau	LIG4, LIG4S, DNA ligase 4
Dynodwyr allanol	OMIM: 601837 HomoloGene: 1736 GeneCards: LIG4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • metal ion binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • ATP binding • DNA ligase (ATP) activity • ligase activity • DNA binding • DNA ligase activity Cydrannau o'r gell • nucleoplasm • DNA ligase IV complex • nonhomologous end joining complex • condensed chromosome • cnewyllyn cell • DNA-dependent protein kinase-DNA ligase 4 complex • cytoplasm • cytoplasmic ribonucleoprotein granule Prosesau biolegol • nucleotide-excision repair, DNA gap filling • double-strand break repair via classical nonhomologous end joining • response to ionizing radiation • DNA recombination • lagging strand elongation • DNA biosynthetic process • cellular response to lithium ion • single strand break repair • cellular response to DNA damage stimulus • Cellraniad • DNA replication • GO:1903310 positive regulation of chromosome organization • establishment of integrated proviral latency • cell cycle • response to X-ray • positive regulation of neurogenesis • DNA ligation involved in DNA recombination • DNA ligation • DNA ligation involved in DNA repair • somatic stem cell population maintenance • GO:0051312, GO:0007083 chromosome organization • T cell receptor V(D)J recombination • neuron apoptotic process • isotype switching • T cell differentiation in thymus • central nervous system development • immunoglobulin V(D)J recombination • double-strand break repair via nonhomologous end joining • positive regulation of fibroblast proliferation • in utero embryonic development • cell population proliferation • V(D)J recombination • pro-B cell differentiation • GO:0100026 DNA repair • response to gamma radiation • double-strand break repair • GO:1904089 negative regulation of neuron apoptotic process • cellular response to ionizing radiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3981	n/a
Ensembl	ENSG00000174405	n/a
UniProt	P49917	n/a
RefSeq (mRNA)	NM_001098268 NM_002312 NM_206937 NM_001330595 NM_001352598 NM_001352599 NM_001352600 NM_001352601 NM_001352602 NM_001352603 NM_001352604 NM_001379095	n/a
RefSeq (protein)	NP_001091738 NP_001317524 NP_002303 NP_996820 NP_001339527 NP_001339528 NP_001339529 NP_001339530 NP_001339531 NP_001339532 NP_001339533 NP_001366024	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LIG4 yw LIG4 a elwir hefyd yn DNA ligase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q33.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LIG4.

• LIG4S

Llyfryddiaeth

• "LIG4 mediates Wnt signalling-induced radioresistance. ". Nat Commun. 2016. PMID 27009971.
• "Molecular and immunological characterization of DNA ligase IV deficiency. ". Clin Immunol. 2016. PMID 26762768.
• "DNA ligase4 as a prognostic marker in nasopharyngeal cancer patients treated with radiotherapy. ". Asian Pac J Cancer Prev. 2014. PMID 25605214.
• "Relevance of LIG4 gene polymorphisms with cancer susceptibility: evidence from a meta-analysis. ". Sci Rep. 2014. PMID 25314918.
• "DNA Ligase IV regulates XRCC4 nuclear localization.". DNA Repair (Amst). 2014. PMID 24984242.