LEF1 Dynodwyr Cyfenwau LEF1 Dynodwyr allanol HomoloGene: 7813 GeneCards: LEF1 Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • armadillo repeat domain binding • estrogen receptor binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • transcription factor binding • estrogen receptor activity • gamma-catenin binding • GO:0031493 histone binding • C2H2 zinc finger domain binding • chromatin binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • GO:0001948, GO:0016582 protein binding • DNA binding, bending • DNA binding • sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • beta-catenin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • cnewyllyn cell • transcription regulator complex • beta-catenin-TCF complex • nucleoplasm • protein-DNA complex Prosesau biolegol • somitogenesis • tongue development • paraxial mesoderm formation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of DNA binding • T cell receptor V(D)J recombination • transcription by RNA polymerase II • cellular response to cytokine stimulus • mammary gland development • negative regulation of interleukin-13 production • odontogenesis of dentin-containing tooth • apoptotic process involved in blood vessel morphogenesis • cell chemotaxis • negative regulation of canonical Wnt signaling pathway • face morphogenesis • neutrophil differentiation • negative regulation of interleukin-5 production • GO:0009373 regulation of transcription, DNA-templated • dentate gyrus development • apoptotic process involved in morphogenesis • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of cell growth • regulation of Wnt signaling pathway • embryonic limb morphogenesis • hypothalamus development • branching involved in blood vessel morphogenesis • trachea gland development • regulation of striated muscle tissue development • positive regulation of cell-cell adhesion • forebrain neuroblast division • eye pigmentation • negative regulation of apoptotic process • sprouting angiogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • positive regulation of epithelial to mesenchymal transition • BMP signaling pathway • positive regulation of cell cycle process • osteoblast differentiation • histone H3 acetylation • formation of radial glial scaffolds • positive regulation of granulocyte differentiation • alpha-beta T cell differentiation • canonical Wnt signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • sensory perception of taste • cellular response to interleukin-4 • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cell development • negative regulation of cell-cell adhesion • negative regulation of interleukin-4 production • negative regulation of striated muscle tissue development • positive regulation of cell migration • Wnt signaling pathway • T-helper 1 cell differentiation • positive regulation of cell proliferation in bone marrow • anatomical structure regression • chorio-allantoic fusion • negative regulation of apoptotic process in bone marrow cell • B cell proliferation • GO:1901313 positive regulation of gene expression • vasculature development • forebrain radial glial cell differentiation • neural crest cell migration • positive regulation of cell population proliferation • forebrain neuron differentiation • histone H4 acetylation • hippocampus development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • Wnt signaling pathway, calcium modulating pathway • steroid hormone mediated signaling pathway • odontoblast differentiation • beta-catenin-TCF complex assembly • epithelial to mesenchymal transition • regulation of cell-cell adhesion • secondary palate development Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn LEF1 yw LEF1 a elwir hefyd yn Lymphoid enhancer-binding factor 1, isoform CRA_b a Lymphoid enhancer binding factor 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q25.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LEF1.
LEF-1
TCF10
TCF7L3
TCF1ALPHA
"Methylprednisolone suppresses the Wnt signaling pathway in chronic lymphocytic leukemia cell line MEC-1 regulated by LEF-1 expression. ". Int J Clin Exp Pathol . 2015. PMID 26339357 . "Overexpression of lymphoid enhancer-binding factor-1 (LEF1) is a novel favorable prognostic factor in childhood acute lymphoblastic leukemia. ". Int J Lab Hematol . 2015. PMID 25955539 . "Diagnostic Utility of Lymphoid Enhancer Binding Factor 1 Immunohistochemistry in Small B-Cell Lymphomas. ". Am J Clin Pathol . 2017. PMID 28395058 . "Expression of LEF1 in mantle cell lymphoma. ". Ann Diagn Pathol . 2017. PMID 28038713 . "High LEF1 expression predicts adverse prognosis in chronic lymphocytic leukemia and may be targeted by ethacrynic acid. ". Oncotarget . 2016. PMID 26950276 . 
