LDHA

LDHA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1I10, 4AJP, 4JNK, 4L4R, 4L4S, 4M49, 4OJN, 4OKN, 4QO7, 4QO8, 4QSM, 4QT0, 4R68, 4R69, 4RLS, 4ZVV
Dynodwyr
Cyfenwau	LDHA, GSD11, HEL-S-133P, LDH1, LDHM, PIG19, lactate dehydrogenase A
Dynodwyr allanol	OMIM: 150000 HomoloGene: 56495 GeneCards: LDHA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • NAD binding • lactate dehydrogenase activity • kinase binding • GO:0001948, GO:0016582 protein binding • catalytic activity • identical protein binding • oxidoreductase activity • L-lactate dehydrogenase activity • cadherin binding Cydrannau o'r gell • cytoplasm • bilen • extracellular exosome • cnewyllyn cell • cytosol Prosesau biolegol • post-embryonic animal organ development • lactate metabolic process • response to hypoxia • glycolytic process • GO:1904578 response to organic cyclic compound • substantia nigra development • response to nutrient • carboxylic acid metabolic process • response to glucose • NAD metabolic process • response to estrogen • pyruvate metabolic process • positive regulation of apoptotic process • response to cAMP • response to hydrogen peroxide • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3939	n/a
Ensembl	ENSG00000134333 ENSG00000288299	n/a
UniProt	P00338	n/a
RefSeq (mRNA)	NM_001135239 NM_001165414 NM_001165415 NM_001165416 NM_005566	n/a
RefSeq (protein)	NP_001128711 NP_001158886 NP_001158887 NP_001158888 NP_005557	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LDHA yw LDHA a elwir hefyd yn L-lactate dehydrogenase A chain a Lactate dehydrogenase a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LDHA.

• LDHM
• GSD11
• PIG19
• HEL-S-133P

Llyfryddiaeth

• "Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival. ". Anticancer Res. 2017. PMID 28314283.
• "Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. ". Oncogene. 2017. PMID 28218905.
• "Prognostic Role of Lactate Dehydrogenase Expression in Urologic Cancers: A Systematic Review and Meta-Analysis. ". Oncol Res Treat. 2016. PMID 27710971.
• "Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells. ". Eur J Pharm Sci. 2017. PMID 27622920.
• "Overexpression of lactate dehydrogenase A in cholangiocarcinoma is correlated with poor prognosis.". Histol Histopathol. 2017. PMID 27615379.