LCP2

LCP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H3H, 1YWO, 2EAP, 2ROR
Dynodwyr
Cyfenwau	LCP2, SLP-76, SLP76, lymphocyte cytosolic protein 2, IMD81
Dynodwyr allanol	OMIM: 601603 HomoloGene: 4065 GeneCards: LCP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • cytosol • TCR signalosome • cell-cell junction • plasma membrane raft Prosesau biolegol • platelet activation • mast cell activation • Fc-epsilon receptor signaling pathway • positive regulation of protein kinase activity • GO:0007243 intracellular signal transduction • T cell receptor signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • transmembrane receptor protein tyrosine kinase signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3937	n/a
Ensembl	ENSG00000043462	n/a
UniProt	Q13094	n/a
RefSeq (mRNA)	NM_005565	n/a
RefSeq (protein)	NP_005556	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LCP2 yw LCP2 a elwir hefyd yn Lymphocyte cytosolic protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q35.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LCP2.

• SLP76
• SLP-76

Llyfryddiaeth

• "SLP76 integrates into the B-cell receptor signaling cascade in chronic lymphocytic leukemia cells and is associated with an aggressive disease course. ". Haematologica. 2016. PMID 27443285.
• "SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling. ". Mol Cell Proteomics. 2015. PMID 25316710.
• "SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation. ". J Biol Chem. 2013. PMID 23935094.
• "Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells. ". PLoS One. 2012. PMID 23071622.
• "Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells.". Sci Signal. 2012. PMID 22786724.