LCMT1

LCMT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3IEI, 3O7W, 3P71
Dynodwyr
Cyfenwau	LCMT1, LCMT, PPMT1, CGI-68, leucine carboxyl methyltransferase 1
Dynodwyr allanol	OMIM: 610286 HomoloGene: 41123 GeneCards: LCMT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • protein methyltransferase activity • S-adenosylmethionine-dependent methyltransferase activity • transferase activity • GO:0001948, GO:0016582 protein binding • protein C-terminal carboxyl O-methyltransferase activity • protein C-terminal leucine carboxyl O-methyltransferase activity Cydrannau o'r gell • cytosol • nucleoplasm Prosesau biolegol • regulation of mitotic cell cycle spindle assembly checkpoint • methylation • C-terminal protein methylation • regulation of glucose metabolic process • regulation of apoptotic process • GO:0106160 negative regulation of protein-containing complex assembly • protein methylation • G2/M transition of mitotic cell cycle Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51451	n/a
Ensembl	ENSG00000205629	n/a
UniProt	Q9UIC8	n/a
RefSeq (mRNA)	NM_001032391 NM_016309 NM_016015	n/a
RefSeq (protein)	NP_001027563 NP_057393	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LCMT1 yw LCMT1 a elwir hefyd yn Leucine carboxyl methyltransferase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LCMT1.

• LCMT
• PPMT1
• CGI-68

Llyfryddiaeth

• "The structural basis for tight control of PP2A methylation and function by LCMT-1. ". Mol Cell. 2011. PMID 21292165.
• "Leucine carboxyl methyltransferase-1 is necessary for normal progression through mitosis in mammalian cells. ". J Biol Chem. 2007. PMID 17724024.
• "The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A. ". Acta Crystallogr D Biol Crystallogr. 2011. PMID 21206058.
• "A LCMT1-PME-1 methylation equilibrium controls mitotic spindle size. ". Cell Cycle. 2015. PMID 25839665.
• "Leucine carboxyl methyltransferase 1 (LCMT1)-dependent methylation regulates the association of protein phosphatase 2A and Tau protein with plasma membrane microdomains in neuroblastoma cells.". J Biol Chem. 2013. PMID 23943618.