LCK

LCK
Strwythurau PDB Human UniProt search: E9PI33 PDBe E9PI33 RCSB Rhestr o ddynodwyr PDB 1BHF, 1BHH, 1CWD, 1CWE, 1FBZ, 1H92, 1IJR, 1KIK, 1LCJ, 1LCK, 1LKK, 1LKL, 1Q68, 1Q69, 1QPC, 1QPD, 1QPE, 1QPJ, 1X27, 2IIM, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2PL0, 2ZM1, 2ZM4, 2ZYB, 3AC1, 3AC2, 3AC3, 3AC4, 3AC5, 3AC8, 3ACJ, 3ACK, 3AD4, 3AD5, 3AD6, 3B2W, 3BRH, 3BYM, 3BYO, 3BYS, 3BYU, 3KMM, 3KXZ, 3LCK, 3MPM, 4D8K, 4C3F
Dynodwyr
Cyfenwau	LCK, LCK proto-oncogene, Src family tyrosine kinase, IMD22, LSK, YT16, p56lck, pp58lck
Dynodwyr allanol	OMIM: 153390 HomoloGene: 3911 GeneCards: LCK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • CD4 receptor binding • ATPase binding • SH2 domain binding • CD8 receptor binding • phosphatidylinositol 3-kinase binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • identical protein binding • protein phosphatase binding • ATP binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • kinase activity • protein serine/threonine phosphatase activity • non-membrane spanning protein tyrosine kinase activity • phosphotyrosine residue binding • protein tyrosine kinase activity • T cell receptor binding • signaling receptor binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • extrinsic component of cytoplasmic side of plasma membrane • immunological synapse • extracellular exosome • pericentriolar material • membrane raft • Cellbilen Prosesau biolegol • B cell receptor signaling pathway • release of sequestered calcium ion into cytosol • hemopoiesis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of T cell receptor signaling pathway • T cell costimulation • GO:0019049, GO:0030683 mitigation of host defenses by virus • platelet activation • T cell differentiation • regulation of cell population proliferation • cellular zinc ion homeostasis • regulation of lymphocyte activation • peptidyl-tyrosine autophosphorylation • T cell receptor signaling pathway • positive regulation of intrinsic apoptotic signaling pathway • leukocyte migration • positive regulation of T cell activation • GO:0016576 protein dephosphorylation • innate immune response • phosphatidylinositol phosphate biosynthetic process • GO:0022415 viral process • protein phosphorylation • activation of cysteine-type endopeptidase activity involved in apoptotic process • cell migration • peptidyl-tyrosine phosphorylation • interleukin-7-mediated signaling pathway • positive regulation of protein kinase B signaling • cell differentiation • positive regulation of heterotypic cell-cell adhesion • positive regulation of leukocyte cell-cell adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3932	n/a
Ensembl	ENSG00000182866	n/a
UniProt	P06239	n/a
RefSeq (mRNA)	NM_001042771 NM_005356 NM_001330468	n/a
RefSeq (protein)	NP_001036236 NP_001317397 NP_005347	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LCK yw LCK a elwir hefyd yn Tyrosine-protein kinase Lck a LCK proto-oncogene, Src family tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1p35.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LCK.

• LSK
• YT16
• IMD22
• p56lck
• pp58lck

Llyfryddiaeth

• "Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells. ". Nat Struct Mol Biol. 2017. PMID 29083415.
• "De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling. ". Sci Signal. 2017. PMID 28096507.
• "Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain. ". J Biol Chem. 2016. PMID 27334919.
• "Identification of LCK mutation in a family with atypical epidermodysplasia verruciformis with T-cell defects and virus-induced squamous cell carcinoma. ". Br J Dermatol. 2016. PMID 27087313.
• "A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization.". PLoS One. 2015. PMID 26147390.