LBR

LBR
Strwythurau PDB Human UniProt search: C9JXK0 PDBe C9JXK0 RCSB Rhestr o ddynodwyr PDB 2DIG
Dynodwyr
Cyfenwau	LBR, DHCR14B, LMN2R, PHA, TDRD18, lamin B receptor, PHASK, C14SR
Dynodwyr allanol	OMIM: 600024 HomoloGene: 2455 GeneCards: LBR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity, acting on the CH-CH group of donors • DNA binding • oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor • GO:0001948, GO:0016582 protein binding • chromo shadow domain binding • lamin binding • delta14-sterol reductase activity • RNA binding • NADPH binding • oxidoreductase activity Cydrannau o'r gell • integral component of membrane • integral component of endoplasmic reticulum membrane • nuclear inner membrane • integral component of nuclear inner membrane • nuclear membrane • nuclear envelope • bilen • cnewyllyn cell • cytoplasm • endoplasmic reticulum membrane • Reticwlwm endoplasmig Prosesau biolegol • cholesterol biosynthetic process • sterol biosynthetic process • neutrophil differentiation • lipid metabolism • steroid biosynthetic process • steroid metabolic process • cholesterol metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3930	n/a
Ensembl	ENSG00000143815	n/a
UniProt	Q14739	n/a
RefSeq (mRNA)	NM_002296 NM_194442	n/a
RefSeq (protein)	NP_002287 NP_919424	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LBR yw LBR a elwir hefyd yn Lamin-B receptor a Lamin B receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1q42.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LBR.

• PHA
• LMN2R
• TDRD18
• DHCR14B

Llyfryddiaeth

• "The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. ". Elife. 2016. PMID 27336722.
• "Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells. ". Biochem Biophys Res Commun. 2016. PMID 27059139.
• "Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR. ". Am J Med Genet A. 2013. PMID 23824842.
• "Lymphohematopoietic licence: sterol C-14 reductase activity of lamin B receptor (Lbr) is essential for neutrophil differentiation. ". J Biosci. 2012. PMID 22581323.
• "Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor.". Mol Biol Cell. 2011. PMID 21795390.