LAMTOR3

LAMTOR3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1SKO, 2ZL1, 3CPT
Dynodwyr
Cyfenwau	LAMTOR3, MAP2K1IP1, MAPBP, MAPKSP1, MP1, PRO0633, Ragulator3, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Dynodwyr allanol	OMIM: 603296 HomoloGene: 10539 GeneCards: LAMTOR3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • guanyl-nucleotide exchange factor activity • GO:0001948, GO:0016582 protein binding • GO:0032947 molecular adaptor activity • kinase activator activity Cydrannau o'r gell • endosome • bilen • late endosome membrane • focal adhesion • Ragulator complex • lysosomal membrane • endosome membrane • extracellular exosome • late endosome • Cellbilen • specific granule membrane • tertiary granule membrane Prosesau biolegol • regulation of TOR signaling • MAPK cascade • cellular response to amino acid stimulus • positive regulation of TOR signaling • neutrophil degranulation • regulation of macroautophagy Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8649	n/a
Ensembl	ENSG00000109270	n/a
UniProt	Q9UHA4	n/a
RefSeq (mRNA)	NM_001243736 NM_021970	n/a
RefSeq (protein)	NP_001230665 NP_068805	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn LAMTOR3 yw LAMTOR3 a elwir hefyd yn Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q23.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn LAMTOR3.

• MP1
• MAPBP
• MAPKSP1
• PRO0633
• MAP2K1IP1
• Ragulator3

Llyfryddiaeth

• "BCL2 induced by LAMTOR3/MAPK is a druggable target of chemoradioresistance in mesenchymal lung cancer. ". Cancer Lett. 2017. PMID 28606806.
• "A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk. ". Biomed Pharmacother. 2015. PMID 25661340.
• "Gastrin-induced proliferation involves MEK partner 1 (MP1). ". In Vitro Cell Dev Biol Anim. 2013. PMID 23408059.
• "MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling. ". J Cell Biochem. 2005. PMID 15547943.
• "Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction.". Dev Cell. 2002. PMID 12479806.