L3MBTL1

L3MBTL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OYX, 1OZ2, 1OZ3, 2PQW, 2RHI, 2RHU, 2RHX, 2RHY, 2RHZ, 2RI2, 2RI3, 2RI5, 2RJC, 2RJD, 2RJE, 2RJF, 3OQ5, 3P8H, 3UWN
Dynodwyr
Cyfenwau	L3MBTL1, H-L(3)MBT, L3MBTL, ZC2HC3, dJ138B7.3, l(3)mbt-like 1 (Drosophila), histone methyl-lysine binding protein, L3MBTL histone methyl-lysine binding protein 1
Dynodwyr allanol	OMIM: 608802 HomoloGene: 41846 GeneCards: L3MBTL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0031493 histone binding • zinc ion binding • SAM domain binding • chromatin binding • metal ion binding • methylated histone binding • GO:0001948, GO:0016582 protein binding • identical protein binding • nucleosome binding Cydrannau o'r gell • Cellbilen • nucleolus • chromatin • condensed chromosome • cnewyllyn cell • nucleoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of cell cycle • GO:0045996 negative regulation of transcription, DNA-templated • regulation of megakaryocyte differentiation • regulation of mitotic nuclear division • regulation of signal transduction by p53 class mediator • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • hemopoiesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26013	n/a
Ensembl	ENSG00000185513	n/a
UniProt	Q9Y468	n/a
RefSeq (mRNA)	NM_032107 NM_015478	n/a
RefSeq (protein)	NP_056293 NP_115479	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn L3MBTL1 yw L3MBTL1 a elwir hefyd yn L3MBTL1, histone methyl-lysine binding protein a Lethal(3)malignant brain tumor-like protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn L3MBTL1.

• L3MBTL
• ZC2HC3
• H-L(3)MBT
• dJ138B7.3

Llyfryddiaeth

• "Characterization of the imprinted polycomb gene L3MBTL, a candidate 20q tumour suppressor gene, in patients with myeloid malignancies. ". Br J Haematol. 2004. PMID 15566354.
• "Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies. ". Proc Natl Acad Sci U S A. 2004. PMID 15123827.
• "L3MBTL1 deficiency directs the differentiation of human embryonic stem cells toward trophectoderm. ". Stem Cells Dev. 2011. PMID 21341991.
• "Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera. ". Blood. 2010. PMID 20585043.
• "Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.". Mol Cell. 2007. PMID 18042461.