KSR1

KSR1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KBE, 1KBF, 2LPE
Dynodwyr
Cyfenwau	KSR1, KSR, RSU2, kinase suppressor of ras 1
Dynodwyr allanol	OMIM: 601132 HomoloGene: 8410 GeneCards: KSR1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • ATP binding • MAP-kinase scaffold activity • protein kinase activity • signal transducer activity • mitogen-activated protein kinase kinase binding • chaperone binding • Hsp90 protein binding • 14-3-3 protein binding Cydrannau o'r gell • cytoplasm • cytosol • endoplasmic reticulum membrane • bilen • Reticwlwm endoplasmig • cell projection • ruffle membrane • Cellbilen • GO:0009327 protein-containing complex Prosesau biolegol • GO:0007243 intracellular signal transduction • MAPK cascade • cAMP-mediated signaling • protein phosphorylation • Ras protein signal transduction • positive regulation of MAPK cascade • regulation of cell population proliferation • regulation of MAP kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8844	n/a
Ensembl	ENSG00000141068	n/a
UniProt	Q8IVT5	n/a
RefSeq (mRNA)	NM_014238 NM_001367810 NM_001394583 NM_001394584 NM_001394585	n/a
RefSeq (protein)	NP_055053 NP_001354739	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KSR1 yw KSR1 a elwir hefyd yn Kinase suppressor of ras 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KSR1.

• KSR
• RSU2

Llyfryddiaeth

• "KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs. ". Mol Cell Biol. 2009. PMID 19188442.
• "Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake. ". Cancer Biol Ther. 2008. PMID 18719367.
• "Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer. ". Pharmacogenomics J. 2015. PMID 25287073.
• "KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. ". Oncogene. 2015. PMID 24909178.
• "Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.". Leuk Res. 2011. PMID 21555152.