KRAS

KRAS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4WA7, 1D8D, 1D8E, 3GFT, 4DSN, 4DSO, 4EPR, 4EPT, 4EPV, 4EPW, 4EPX, 4EPY, 4L8G, 4LDJ, 4LPK, 4LRW, 4LUC, 4LV6, 4LYF, 4LYH, 4LYJ, 4M1O, 4M1S, 4M1T, 4M1W, 4M1Y, 4M21, 4M22, 4NMM, 4OBE, 4PZY, 4PZZ, 4Q01, 4Q02, 4Q03, 4QL3, 4TQ9, 4TQA, 4DST, 4DSU, 5F2E,%%s2MSC, 2MSD, 2MSE
Dynodwyr
Cyfenwau	KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RALD, RASK2, K-ras, KRAS proto-oncogene, GTPase, c-Ki-ras2, OES, c-Ki-ras, K-Ras 2, 'C-K-RAS, K-Ras, Kirsten RAt Sarcoma virus, Kirsten Rat Sarcoma virus
Dynodwyr allanol	OMIM: 190070 HomoloGene: 37990 GeneCards: KRAS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • LRR domain binding • GDP binding • GO:0032403 protein-containing complex binding • GTP binding • GMP binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • Cellbilen • mitocondria • membrane raft Prosesau biolegol • visual learning • GO:1904089 negative regulation of neuron apoptotic process • response to mineralocorticoid • positive regulation of protein phosphorylation • regulation of long-term neuronal synaptic plasticity • regulation of protein stability • epidermal growth factor receptor signaling pathway • positive regulation of MAP kinase activity • cytokine-mediated signaling pathway • negative regulation of cell differentiation • stimulatory C-type lectin receptor signaling pathway • response to glucocorticoid • MAPK cascade • axon guidance • Fc-epsilon receptor signaling pathway • positive regulation of nitric-oxide synthase activity • forebrain astrocyte development • endocrine signaling • positive regulation of NF-kappaB transcription factor activity • homeostasis of number of cells within a tissue • striated muscle cell differentiation • Ras protein signal transduction • epithelial tube branching involved in lung morphogenesis • regulation of synaptic transmission, GABAergic • actin cytoskeleton organization • leukocyte migration • GO:0072468 signal transduction • positive regulation of Rac protein signal transduction • GO:1901313 positive regulation of gene expression • positive regulation of cell population proliferation • ERBB2 signaling pathway • liver development • positive regulation of cellular senescence • female pregnancy • response to isolation stress Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3845	n/a
Ensembl	ENSG00000133703	n/a
UniProt	P01116	n/a
RefSeq (mRNA)	NM_004985 NM_033360 NM_001369786 NM_001369787	n/a
RefSeq (protein)	NP_004976 NP_203524 NP_001356715 NP_001356716 NP_004976.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KRAS yw KRAS a elwir hefyd yn V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b a KRAS proto-oncogene, GTPase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p12.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KRAS.

• NS
• NS3
• CFC2
• RALD
• K-Ras
• KRAS1
• KRAS2
• RASK2
• KI-RAS
• C-K-RAS
• K-RAS2A
• K-RAS2B
• K-RAS4A
• K-RAS4B
• c-Ki-ras2

Llyfryddiaeth

• "Synergistic activity of sorafenib and betulinic acid against clonogenic activity of non-small cell lung cancer cells. ". Cancer Sci. 2017. PMID 28846180.
• "The prognostic value of KRAS mutation by cell-free DNA in cancer patients: A systematic review and meta-analysis. ". PLoS One. 2017. PMID 28796802.
• "Mucinous Cystic Neoplasms Lined by Abundant Mucinous Epithelium Frequently Involve KRAS Mutations and Malignant Progression. ". Anticancer Res. 2017. PMID 29187496.
• "FNA smears of pancreatic ductal adenocarcinoma are superior to formalin-fixed paraffin-embedded tissue as a source of DNA: Comparison of targeted KRAS amplification and genotyping in matched preresection and postresection samples. ". Cancer Cytopathol. 2017. PMID 29024530.
• "Prognostic value of KRAS codon 13 gene mutation for overall survival in colorectal cancer: Direct and indirect comparison meta-analysis.". Medicine (Baltimore). 2017. PMID 28858102.