KPNB1

KPNB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1F59, 1IBR, 1M5N, 1O6O, 1O6P, 1QGK, 1QGR, 2P8Q, 2Q5D, 2QNA, 3LWW, 3W5K
Dynodwyr
Cyfenwau	KPNB1, IMB1, IPO1, IPOB, Impnb, NTF97, karyopherin subunit beta 1
Dynodwyr allanol	OMIM: 602738 HomoloGene: 1707 GeneCards: KPNB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • Hsp90 protein binding • protein domain specific binding • zinc ion binding • GO:0001948, GO:0016582 protein binding • nuclear localization sequence binding • enzyme binding • RNA binding • importin-alpha family protein binding Cydrannau o'r gell • nuclear membrane • bilen • nuclear periphery • nuclear pore • endoplasmic reticulum tubular network • nucleoplasm • extracellular exosome • cnewyllyn cell • nuclear envelope • extracellular region • cytoplasm • cytosol • specific granule lumen • ficolin-1-rich granule lumen • host cell • cytoplasmic stress granule • GO:0009327 protein-containing complex Prosesau biolegol • GO:0046795 intracellular transport of virus • apoptotic DNA fragmentation • Ran protein signal transduction • establishment of protein localization • mitotic spindle assembly • protein transport • mitotic metaphase plate congression • intracellular protein transport • astral microtubule organization • mitotic chromosome movement towards spindle pole • establishment of mitotic spindle localization • NLS-bearing protein import into nucleus • modulation by virus of host cellular process • protein import into nucleus • ribosomal protein import into nucleus • GO:0022415 viral process • neutrophil degranulation • regulation of cholesterol biosynthetic process • GO:0015915 transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3837	n/a
Ensembl	ENSG00000108424	n/a
UniProt	Q14974	n/a
RefSeq (mRNA)	NM_002265 NM_001276453	n/a
RefSeq (protein)	NP_001263382 NP_002256	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KPNB1 yw KPNB1 a elwir hefyd yn Importin subunit beta-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KPNB1.

• IMB1
• IPO1
• IPOB
• Impnb
• NTF97

Llyfryddiaeth

• "Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway. ". Biochem Biophys Res Commun. 2016. PMID 27568288.
• "Upregulation of nuclear transporter, Kpnβ1, contributes to accelerated cell proliferation- and cell adhesion-mediated drug resistance (CAM-DR) in diffuse large B-cell lymphoma. ". J Cancer Res Clin Oncol. 2016. PMID 26498772.
• "Upregulation of KPNβ1 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis. ". Tumour Biol. 2016. PMID 26242264.
• "Hyper-dependence of breast cancer cell types on the nuclear transporter Importin β1. ". Biochim Biophys Acta. 2015. PMID 25960398.
• "Suppression of the nuclear transporter-KPNβ1 expression inhibits tumor proliferation in hepatocellular carcinoma.". Med Oncol. 2015. PMID 25794490.