KMT2A Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AGH , 2J2S , 2JYI , 2KKF , 2KU7 , 2KYU , 2LXS , 2LXT , 2MTN , 2W5Y , 2W5Z , 3EG6 , 3EMH , 3LQI , 3LQJ , 3P4F , 3U85 , 3U88 , 4ESG , 4GQ6 , 4NW3 , 5F6L , 5F5E
Dynodwyr Cyfenwau KMT2A Dynodwyr allanol HomoloGene: 4338 GeneCards: KMT2A Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0102674, GO:0102675 methyltransferase activity • transferase activity • DNA binding • protein homodimerization activity • minor groove of adenine-thymine-rich DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • zinc ion binding • chromatin binding • metal ion binding • core promoter sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • unmethylated CpG binding • lysine-acetylated histone binding • identical protein binding • histone-lysine N-methyltransferase activity • histone methyltransferase activity (H3-K4 specific) • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • nucleoplasm • cnewyllyn cell • histone methyltransferase complex • cytosol • MLL1 complex Prosesau biolegol • visual learning • response to potassium ion • GO:0009373 regulation of transcription, DNA-templated • gwybyddiaeth • positive regulation of transporter activity • positive regulation of cellular response to drug • response to light stimulus • proses rythmig • regulation of short-term neuronal synaptic plasticity • histone H3-K4 trimethylation • membrane depolarization • regulation of histone H3-K4 methylation • regulation of histone H3-K9 acetylation • transcription by RNA polymerase II • post-embryonic development • peptidyl-lysine monomethylation • spleen development • circadian regulation of gene expression • regulation of histone H3-K14 acetylation • transcription, DNA-templated • regulation of histone H3-K27 acetylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • DNA methylation • histone H3-K4 methylation • methylation • positive regulation of histone H3-K4 methylation • exploration behavior • embryonic hemopoiesis • histone H3-K4 dimethylation • regulation of gene expression • homeostasis of number of cells within a tissue • histone H4-K16 acetylation • definitive hemopoiesis • anterior/posterior pattern specification • negative regulation of cell population proliferation • GO:0097285 apoptotic process • regulation of megakaryocyte differentiation • regulation of hematopoietic stem cell differentiation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0034622 protein-containing complex assembly • negative regulation of DNA methylation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn KMT2A yw KMT2A a elwir hefyd yn Lysine methyltransferase 2A (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q23.3.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KMT2A.
HRX
MLL
MLL1
TRX1
ALL-1
CXXC7
HTRX1
MLL1A
WDSTS
"Therapy-related myeloid neoplasm in an 18-year-old boy with B-lymphoblastic leukemia. ". Exp Mol Pathol . 2017. PMID 29155023 . "Comprehensive genetic analysis of donor cell derived leukemia with KMT2A rearrangement. ". Pediatr Blood Cancer . 2018. PMID 28921816 . "Identification of novel biomarkers for MLL-translocated acute myeloid leukemia. ". Exp Hematol . 2017. PMID 28911906 . "Wiedemann-Steiner syndrome: Novel pathogenic variant and review of literature. ". Eur J Med Genet . 2017. PMID 28359930 . "The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion. ". J Natl Cancer Inst . 2017. PMID 28131992 . 
