KLKB1

KLKB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4OGY, 2ANW, 4OGX, 4ZJ4, 2ANY, 4ZJ5, 4ZJ6
Dynodwyr
Cyfenwau	KLKB1, KLK3, PPK, PKKD, PKK, kallikrein B1
Dynodwyr allanol	OMIM: 229000 HomoloGene: 68097 GeneCards: KLKB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • serine-type peptidase activity • serine-type endopeptidase activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • hydrolase activity Cydrannau o'r gell • extracellular exosome • Cellbilen • extracellular region • extracellular space Prosesau biolegol • positive regulation of fibrinolysis • zymogen activation • Factor XII activation • proteolysis • fibrinolysis • plasminogen activation • extracellular matrix disassembly • inflammatory response • hemostasis • blood coagulation • blood coagulation, intrinsic pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3818	n/a
Ensembl	ENSG00000164344	n/a
UniProt	P03952	n/a
RefSeq (mRNA)	NM_000892 NM_001318394 NM_001318396	n/a
RefSeq (protein)	NP_000883 NP_001305323 NP_001305325	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KLKB1 yw KLKB1 a elwir hefyd yn Kallikrein B1 a Plasma kallikrein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q35.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KLKB1.

• PKK
• PPK
• KLK3
• PKKD

Llyfryddiaeth

• "Genetic Determinants of C1 Inhibitor Deficiency Angioedema Age of Onset. ". Int Arch Allergy Immunol. 2017. PMID 29130992.
• "KLKB1 mRNA overexpression: A novel molecular biomarker for the diagnosis of chronic lymphocytic leukemia. ". Clin Biochem. 2015. PMID 25891023.
• "The old and the new in prekallikrein deficiency: historical context and a family from Argentina with PK deficiency due to a new mutation (Arg541Gln) in exon 14 associated with a common polymorphysm (Asn124Ser) in exon 5. ". Semin Thromb Hemost. 2014. PMID 25075649.
• "Plasma prekallikrein levels are positively associated with circulating lipid levels and the metabolic syndrome in children. ". Appl Physiol Nutr Metab. 2010. PMID 20725119.
• "Management of prekallikrein deficiency during cardiac surgery.". Thromb Haemost. 2010. PMID 20135073.