KIF5A

KIF5A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4UXT, 4UXY, 4UY0
Dynodwyr
Cyfenwau	KIF5A, D12S1889, MY050, NKHC, SPG10, kinesin family member 5A, NEIMY, ALS25
Dynodwyr allanol	OMIM: 602821 HomoloGene: 55861 GeneCards: KIF5A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • microtubule motor activity • microtubule binding • GO:0001948, GO:0016582 protein binding • cytoskeletal motor activity • plus-end-directed microtubule motor activity • ATP binding • kinesin binding • ATPase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • kinesin complex • neuronal cell body • ciliary rootlet • perinuclear region of cytoplasm • neuron projection • microtubule • Cytosgerbwd • dendrite cytoplasm • synapse • axon cytoplasm Prosesau biolegol • GO:0034613 protein localization • cytoskeleton-dependent intracellular transport • antigen processing and presentation of exogenous peptide antigen via MHC class II • axon guidance • chemical synaptic transmission • retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum • vesicle-mediated transport • microtubule-based movement • anterograde dendritic transport of neurotransmitter receptor complex • synaptic vesicle transport • anterograde axonal protein transport • retrograde neuronal dense core vesicle transport Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3798	n/a
Ensembl	ENSG00000155980	n/a
UniProt	Q12840	n/a
RefSeq (mRNA)	NM_004984 NM_001354705 NM_032624	n/a
RefSeq (protein)	NP_004975 NP_001341634	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KIF5A yw KIF5A a elwir hefyd yn Kinesin family member 5A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KIF5A.

• NKHC
• MY050
• NEIMY
• SPG10
• D12S1889

Llyfryddiaeth

• "Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia. ". PLoS One. 2017. PMID 28678816.
• "KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis. ". Sci Rep. 2017. PMID 28676645.
• "A novel mutation in KIF5Ain a Malian family with spastic paraplegia and sensory loss. ". Ann Clin Transl Neurol. 2017. PMID 28382308.
• "Toxic effects of zinc ions on kinesin - Potential molecular cause of impaired intracellular transport. ". Toxicol Lett. 2017. PMID 28122263.
• "KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.". Ann Neurol. 2016. PMID 27463701.