KHSRP

KHSRP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2HH2, 2HH3, 2JVZ, 2OPU, 2OPV, 4B8T
Dynodwyr
Cyfenwau	KHSRP, FBP2, FUBP2, KSRP, KH-type splicing regulatory protein, p75
Dynodwyr allanol	OMIM: 603445 HomoloGene: 2734 GeneCards: KHSRP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • mRNA binding • mRNA 3'-UTR AU-rich region binding • RNA binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • nucleoplasm • cytoplasmic stress granule • cnewyllyn cell • exosome (RNase complex) Prosesau biolegol • mRNA transport • GO:0009373 regulation of transcription, DNA-templated • mRNA catabolic process • RNA splicing, via transesterification reactions • mRNA processing • transcription, DNA-templated • regulation of miRNA metabolic process • RNA splicing • cellular response to cytokine stimulus • negative regulation of nitric oxide biosynthetic process • positive regulation of mRNA catabolic process • 3'-UTR-mediated mRNA destabilization • regulation of mRNA stability • GO:0061715 miRNA metabolic process • GO:0015915 transport • negative regulation of low-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8570	n/a
Ensembl	ENSG00000088247	n/a
UniProt	Q92945	n/a
RefSeq (mRNA)	NM_003685 NM_001366299 NM_001366300	n/a
RefSeq (protein)	NP_003676 NP_001353228 NP_001353229	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KHSRP yw KHSRP a elwir hefyd yn Far upstream element-binding protein 2 a KH-type splicing regulatory protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KHSRP.

• FBP2
• KSRP
• FUBP2

Llyfryddiaeth

• "Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression. ". PLoS One. 2015. PMID 25993413.
• "KSRP controls pleiotropic cellular functions. ". Semin Cell Dev Biol. 2014. PMID 24845017.
• "Overexpression of KH-type splicing regulatory protein regulates proliferation, migration, and implantation ability of osteosarcoma. ". Int J Oncol. 2016. PMID 27573585.
• "miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition. ". Cell Rep. 2016. PMID 27396342.
• "The far-upstream element-binding protein 2 is correlated with proliferation and doxorubicin resistance in human breast cancer cell lines.". Tumour Biol. 2016. PMID 26810065.