KDM4D

KDM4D
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DXT, 3DXU, 4D6Q, 4D6R, 4D6S, 4HON, 4HOO, 5FP9, 5F5A, 5FP8, 5FPA, 5FPB, 5FP4, 5F5C
Dynodwyr
Cyfenwau	KDM4D, JMJD2D, lysine demethylase 4D
Dynodwyr allanol	OMIM: 609766 HomoloGene: 69244 GeneCards: KDM4D
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity • dioxygenase activity • metal ion binding • histone demethylase activity • histone H3-methyl-lysine-9 demethylase activity • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • chromatin binding • damaged DNA binding • chromatin DNA binding • methylated histone binding Cydrannau o'r gell • blood microparticle • cnewyllyn cell • nucleoplasm • site of double-strand break • pericentric heterochromatin • histone methyltransferase complex Prosesau biolegol • regulation of protein phosphorylation • cellular response to ionizing radiation • GO:0009373 regulation of transcription, DNA-templated • positive regulation of chromatin binding • double-strand break repair via homologous recombination • transcription, DNA-templated • positive regulation of double-strand break repair via nonhomologous end joining • histone H3-K9 demethylation • GO:1901227 negative regulation of transcription by RNA polymerase II • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • cellular response to DNA damage stimulus • negative regulation of histone H3-K9 trimethylation • chromatin remodeling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	55693	n/a
Ensembl	ENSG00000186280	n/a
UniProt	Q6B0I6	n/a
RefSeq (mRNA)	NM_018039	n/a
RefSeq (protein)	NP_060509	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KDM4D yw KDM4D a elwir hefyd yn Lysine demethylase 4D (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDM4D.

• JMJD2D

Llyfryddiaeth

• "The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites. ". Cell Cycle. 2015. PMID 25714495.
• "Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. ". PLoS One. 2012. PMID 22514644.
• "Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases. ". Structure. 2013. PMID 23219879.
• "H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. ". Nucleic Acids Res. 2017. PMID 27679476.
• "Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.". Anticancer Res. 2016. PMID 27630312.