KDM2A

KDM2A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2YU1, 2YU2, 4BBQ
Dynodwyr
Cyfenwau	KDM2A, CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA, lysine demethylase 2A
Dynodwyr allanol	OMIM: 605657 HomoloGene: 56564 GeneCards: KDM2A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • oxidoreductase activity • zinc ion binding • dioxygenase activity • metal ion binding • histone demethylase activity • GO:0001948, GO:0016582 protein binding • histone H3-methyl-lysine-36 demethylase activity • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • nucleoplasm • cnewyllyn cell Prosesau biolegol • double-strand break repair via nonhomologous end joining • GO:0009373 regulation of transcription, DNA-templated • histone H3-K36 demethylation • transcription, DNA-templated • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of transcription by competitive promoter binding • circadian regulation of gene expression • regulation of circadian rhythm • proses rythmig Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	22992	n/a
Ensembl	ENSG00000173120	n/a
UniProt	Q9Y2K7	n/a
RefSeq (mRNA)	NM_001256405 NM_012308	n/a
RefSeq (protein)	NP_001243334 NP_036440	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KDM2A yw KDM2A a elwir hefyd yn Lysine demethylase 2A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KDM2A.

• FBL7
• CXXC8
• FBL11
• FBXL11
• JHDM1A
• LILINA

Llyfryddiaeth

• "Histone demethylase KDM2A promotes tumor cell growth and migration in gastric cancer. ". Tumour Biol. 2015. PMID 25245333.
• "CxxC-ZF domain is needed for KDM2A to demethylate histone in rDNA promoter in response to starvation. ". Cell Struct Funct. 2014. PMID 24553073.
• "Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation. ". Mol Cell Biol. 2015. PMID 26416883.
• "Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer. ". Mol Carcinog. 2016. PMID 26207617.
• "Fbxl11 Is a Novel Negative Element of the Mammalian Circadian Clock.". J Biol Rhythms. 2015. PMID 26037310.