KCNMA1

KCNMA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K44, 3MT5, 3NAF
Dynodwyr
Cyfenwau	KCNMA1, BKTM, KCa1.1, MaxiK, SAKCA, SLO, SLO-ALPHA, SLO1, bA205K10.1, mSLO1, hSlo, potassium calcium-activated channel subfamily M alpha 1, CADEDS, PNKD3, IEG16, LIWAS
Dynodwyr allanol	OMIM: 600150 HomoloGene: 1693 GeneCards: KCNMA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • potassium channel activity • metal ion binding • voltage-gated ion channel activity • ion channel activity • GO:0001948, GO:0016582 protein binding • voltage-gated potassium channel activity • actin binding • calcium-activated potassium channel activity • large conductance calcium-activated potassium channel activity • identical protein binding • outward rectifier potassium channel activity Cydrannau o'r gell • integral component of membrane • bilen • voltage-gated potassium channel complex • Cellbilen • apical plasma membrane • caveola • postsynaptic membrane Prosesau biolegol • response to hypoxia • Piso • regulation of membrane potential • regulation of ion transmembrane transport • negative regulation of cell volume • cludo ïon • GO:0097301 cellular potassium ion homeostasis • response to carbon monoxide • response to osmotic stress • response to calcium ion • potassium ion transport • transmembrane transport • positive regulation of apoptotic process • smooth muscle contraction involved in micturition • potassium ion transmembrane transport • relaxation of vascular associated smooth muscle • cludo transmembrane rhwng ïonau Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3778	n/a
Ensembl	ENSG00000156113	n/a
UniProt	Q12791	n/a
RefSeq (mRNA)	NM_001014797 NM_001161352 NM_001161353 NM_001271518 NM_001271519 NM_001271520 NM_001271521 NM_001271522 NM_002247 NM_001322829 NM_001322830 NM_001322832 NM_001322835 NM_001322836 NM_001322837 NM_001322838 NM_001322839	n/a
RefSeq (protein)	NP_001014797 NP_001154824 NP_001154825 NP_001258447 NP_001258448 NP_001258449 NP_001258450 NP_001258451 NP_001309758 NP_001309759 NP_001309761 NP_001309764 NP_001309765 NP_001309766 NP_001309767 NP_001309768 NP_002238 NP_001258448.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCNMA1 yw KCNMA1 a elwir hefyd yn Calcium-activated potassium channel subunit alpha-1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCNMA1.

• SLO
• BKTM
• SLO1
• hSlo
• MaxiK
• PNKD3
• SAKCA
• mSLO1
• CADEDS
• KCa1.1
• SLO-ALPHA
• bA205K10.1

Llyfryddiaeth

• "Understanding the conformational motions of RCK gating rings. ". J Gen Physiol. 2017. PMID 28246116.
• "Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. ". Cell Death Dis. 2016. PMID 27763639.
• "A New Splice Variant of Large Conductance Ca2+-activated K+ (BK) Channel α Subunit Alters Human Chondrocyte Function. ". J Biol Chem. 2016. PMID 27758860.
• "Homozygous KCNMA1 mutation as a cause of cerebellar atrophy, developmental delay and seizures. ". Hum Genet. 2016. PMID 27567911.
• "BK K+ channel blockade inhibits radiation-induced migration/brain infiltration of glioblastoma cells.". Oncotarget. 2016. PMID 26893360.