KCNA4

KCNA4
Dynodwyr
Cyfenwau	KCNA4, HBK4, HK1, HPCN2, HUKII, KCNA4L, KCNA8, KV1.4, PCN2, potassium voltage-gated channel subfamily A member 4, MCIDDS
Dynodwyr allanol	OMIM: 176266 HomoloGene: 20514 GeneCards: KCNA4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • potassium channel activity • potassium ion binding • voltage-gated ion channel activity • ion channel activity • GO:0001948, GO:0016582 protein binding • voltage-gated potassium channel activity • delayed rectifier potassium channel activity Cydrannau o'r gell • integral component of membrane • cell projection • bilen • voltage-gated potassium channel complex • Cellbilen • axon • integral component of plasma membrane • dendritic spine Prosesau biolegol • regulation of ion transmembrane transport • cludo ïon • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • protein homooligomerization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3739	n/a
Ensembl	ENSG00000182255	n/a
UniProt	P22459	n/a
RefSeq (mRNA)	NM_002233	n/a
RefSeq (protein)	NP_002224	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KCNA4 yw KCNA4 a elwir hefyd yn Potassium voltage-gated channel subfamily A member 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KCNA4.

• HK1
• HBK4
• PCN2
• HPCN2
• HUKII
• KCNA8
• KV1.4
• KCNA4L

Llyfryddiaeth

• "Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in voltage-gated potassium channels. ". J Biol Chem. 2008. PMID 18640987.
• "Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue. ". Mol Pharmacol. 2008. PMID 17959711.
• "Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2. ". Eur J Neurosci. 2006. PMID 17156368.
• "N type rapid inactivation in human Kv1.4 channels: functional role of a putative C-terminal helix. ". Mol Membr Biol. 2005. PMID 16308273.
• "Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation.". Mol Pharmacol. 2002. PMID 12065763.