KAT8

KAT8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2GIV, 2PQ8, 2Y0M, 3QAH, 3TOA, 3TOB, 4DNC
Dynodwyr
Cyfenwau	KAT8, MOF, MYST1, ZC2HC8, hMOF, lysine acetyltransferase 8, LIGOWS
Dynodwyr allanol	OMIM: 609912 HomoloGene: 41676 GeneCards: KAT8
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • transcription factor binding • metal ion binding • histone acetyltransferase activity (H4-K8 specific) • histone acetyltransferase activity • histone acetyltransferase activity (H4-K5 specific) • methylated histone binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase activity (H4-K16 specific) • enzyme binding • acetyltransferase activity • acyltransferase activity • GO:0031493 histone binding Cydrannau o'r gell • nucleoplasm • Cromosom • MLL1 complex • histone acetyltransferase complex • cnewyllyn cell • kinetochore • MSL complex • nuclear matrix Prosesau biolegol • myeloid cell differentiation • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • histone H4-K5 acetylation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • regulation of autophagy • histone H4-K16 acetylation • GO:0045996 negative regulation of transcription, DNA-templated • histone H4-K8 acetylation • histone acetylation • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	84148	n/a
Ensembl	ENSG00000103510	n/a
UniProt	Q9H7Z6	n/a
RefSeq (mRNA)	NM_032188 NM_182958	n/a
RefSeq (protein)	NP_115564 NP_892003	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn KAT8 yw KAT8 a elwir hefyd yn Lysine acetyltransferase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn KAT8.

• MOF
• hMOF
• MYST1
• ZC2HC8

Llyfryddiaeth

• "The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells. ". Cell Reprogram. 2015. PMID 26091365.
• "Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma. ". Int J Oncol. 2015. PMID 25873202.
• "Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation. ". J Biol Chem. 2016. PMID 27382063.
• "KAT8 Regulates Androgen Signaling in Prostate Cancer Cells. ". Mol Endocrinol. 2016. PMID 27268279.
• "A multifaceted role for MOF histone modifying factor in genome maintenance.". Mech Ageing Dev. 2017. PMID 27038808.