JMJD6 Dynodwyr Cyfenwau JMJD6 Dynodwyr allanol OMIM: 604914 HomoloGene: 9046 GeneCards: JMJD6 Ontoleg y genyn Gweithrediad moleciwlaidd • iron ion binding • protein homodimerization activity • dioxygenase activity • metal ion binding • histone H3-methyl-arginine-2 demethylase activity • GO:0001948, GO:0016582 protein binding • histone H3-methyl-arginine-3 demethylase activity • single-stranded RNA binding • RNA binding • identical protein binding • oxidoreductase activity • peptidyl-lysine 5-dioxygenase activity • histone demethylase activity • signaling receptor activity • GO:0001105 transcription coactivator activity • demethylase activity • oxidative RNA demethylase activity • P-TEFb complex binding Cydrannau o'r gell • cytosol • Cellbilen • nucleoplasm • nucleolus • cnewyllyn cell • ribonucleoprotein complex • cytoplasm Prosesau biolegol • recognition of apoptotic cell • cell differentiation • GO:0009373 regulation of transcription, DNA-templated • T cell differentiation in thymus • kidney development • lung development • histone H3-R2 demethylation • mRNA processing • sprouting angiogenesis • regulation of mRNA splicing, via spliceosome • transcription, DNA-templated • histone H4-R3 demethylation • multicellular organism development • apoptotic cell clearance • heart development • cell surface receptor signaling pathway • blood vessel development • retina development in camera-type eye • RNA splicing • macrophage activation • peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine • erythrocyte development • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein demethylation • oxidative RNA demethylation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • protein homooligomerization Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn JMJD6 yw JMJD6 a elwir hefyd yn Arginine demethylase and lysine hydroxylase (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn JMJD6.
"The polyserine domain of the lysyl-5 hydroxylase Jmjd6 mediates subnuclear localization. ". Biochem J . 2013. PMID 23688307 . "High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma. ". Tumour Biol . 2013. PMID 23595221 . "Elevated expression of JMJD6 is associated with oral carcinogenesis and maintains cancer stemness properties. ". Carcinogenesis . 2016. PMID 26645717 . "Role of JMJD6 in Breast Tumourigenesis. ". PLoS One . 2015. PMID 25951181 . "Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection. ". Sci Rep . 2014. PMID 25219359 . 
