JAG1

JAG1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2KB9, 2VJ2, 4CBZ, 4CC0, 4CC1, 4XI7, 5BO1
Dynodwyr
Cyfenwau	JAG1, Jag1, ABE2, Gsfabe2, Htu, Ozz, Ser-1, AGS, AHD, AWS, CD339, HJ1, JAGL1, jagged 1, AGS1, DCHE, jagged canonical Notch ligand 1, CMT2HH
Dynodwyr allanol	OMIM: 601920 HomoloGene: 180 GeneCards: JAG1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• calcium ion binding; • structural molecule activity; • Notch binding; • GO:0001948, GO:0016582 protein binding; • growth factor activity; • phospholipid binding;
Cydrannau o'r gell	• integral component of membrane; • adherens junction; • Cellbilen; • apical part of cell; • integral component of plasma membrane; • extracellular region; • apical plasma membrane; • bilen;
Prosesau biolegol	• Notch signaling pathway; • T cell mediated immunity; • negative regulation of fat cell differentiation; • pulmonary valve morphogenesis; • glomerular visceral epithelial cell development; • endocardial cushion cell development; • loop of Henle development; • negative regulation of neuron differentiation; • distal tubule development; • pulmonary artery morphogenesis; • cardiac septum morphogenesis; • negative regulation of cell differentiation; • response to muramyl dipeptide; • ciliary body morphogenesis; • aorta morphogenesis; • nervous system development; • keratinocyte differentiation; • cardiac neural crest cell development involved in outflow tract morphogenesis; • neuronal stem cell population maintenance; • negative regulation of stem cell differentiation; • multicellular organism development; • cell communication; • blood vessel remodeling; • inner ear auditory receptor cell differentiation; • positive regulation of osteoblast differentiation; • regulation of cell population proliferation; • angiogenesis; • nephron development; • animal organ morphogenesis; • cell fate determination; • inner ear development; • endothelial cell differentiation; • camera-type eye development; • myoblast differentiation; • cardiac right ventricle morphogenesis; • morphogenesis of an epithelial sheet; • positive regulation of myeloid cell differentiation; • positive regulation of Notch signaling pathway; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • Notch signaling involved in heart development; • negative regulation of endothelial cell differentiation; • regulation of signaling receptor activity; • negative regulation of cell-matrix adhesion; • negative regulation of cell-cell adhesion; • negative regulation of cell migration; • hemopoiesis; • aortic valve morphogenesis; • cardiac epithelial to mesenchymal transition; • positive regulation of cardiac epithelial to mesenchymal transition; • negative regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	182
	n/a
	ENSG00000101384
	n/a
	P78504
	n/a
	NM_000214
	n/a
	NP_000205
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn JAG1 yw JAG1 a elwir hefyd yn Jagged 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 20, band 20p12.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn JAG1.

AGS
AHD
AWS
HJ1
AGS1
CD339
JAGL1

Llyfryddiaeth[golygu | golygu cod]

"JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer. ". PLoS One. 2016. PMID 26930648.
"Potential Involvement of Jagged1 in Metastatic Progression of Human Breast Carcinomas. ". Clin Chem. 2016. PMID 26721293.
"High expression of the Notch ligand Jagged-1 is associated with poor prognosis after surgery for colorectal cancer. ". Cancer Sci. 2016. PMID 27589478.
"Jagged1 Instructs Macrophage Differentiation in Leprosy. ". PLoS Pathog. 2016. PMID 27532668.
"Jagged1 DNA Copy Number Variation Is Associated with Poor Outcome in Liver Cancer.". Am J Pathol. 2016. PMID 27315779.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] JAG1 - Cronfa NCBI

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[2]