ITSN1

ITSN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1KI1, 2KGR, 2KHN, 3QBV, 4IIM
Dynodwyr
Cyfenwau	ITSN1, ITSN, SH3D1A, SH3P17, intersectin 1
Dynodwyr allanol	OMIM: 602442 HomoloGene: 2277 GeneCards: ITSN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • metal ion binding • GO:0001948, GO:0016582 protein binding • kinase activator activity • GO:0032947 molecular adaptor activity • proline-rich region binding • guanyl-nucleotide exchange factor activity Cydrannau o'r gell • cytosol • cell projection • bilen • Cellbilen • endocytic vesicle • synapse • cell junction • neuron projection • clathrin-coated pit • endomembrane system • lamellipodium • calyx of Held • presynaptic endocytic zone • cnewyllyn cell • nuclear envelope • cytoplasm • endosome • GO:0016023 cytoplasmic vesicle • recycling endosome • neuronal cell body • dendritic spine • apical dendrite • intracellular vesicle • postsynaptic actin cytoskeleton • glutamatergic synapse Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of protein kinase B signaling • GO:0007243 intracellular signal transduction • endocytosis • ephrin receptor signaling pathway • synaptic vesicle endocytosis • positive regulation of apoptotic process • positive regulation of phosphorylation • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • small GTPase mediated signal transduction • membrane organization • GO:0022415 viral process • G protein-coupled receptor signaling pathway • positive regulation of kinase activity • exocytosis • protein transport • brain development • positive regulation of growth hormone secretion • positive regulation of dendritic spine development • regulation of modification of postsynaptic actin cytoskeleton • positive regulation of caveolin-mediated endocytosis • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6453	n/a
Ensembl	ENSG00000205726	n/a
UniProt	Q15811 Q6J334	n/a
RefSeq (mRNA)	NM_001001132 NM_003024 NM_001331008 NM_001331009 NM_001331010 NM_001331011 NM_001331012	n/a
RefSeq (protein)	NP_001001132 NP_001317937 NP_001317938 NP_001317939 NP_001317940 NP_001317941 NP_003015	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITSN1 yw ITSN1 a elwir hefyd yn Intersectin 1 isoform 10 ac Intersectin 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 21, band 21q22.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITSN1.

• ITSN
• SH3D1A
• SH3P17

Llyfryddiaeth

• "Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. ". Neuroreport. 2011. PMID 21876463.
• "Intersectin1-s is involved in migration and invasion of human glioma cells. ". J Neurosci Res. 2011. PMID 21503949.
• "Silencing Intersectin 1 Slows Orthotopic Neuroblastoma Growth in Mice. ". J Pediatr Hematol Oncol. 2017. PMID 28787396.
• "Intersectin1-S, a multidomain adapter protein, is essential for malignant glioma proliferation. ". Glia. 2015. PMID 25832561.
• "Intersectin 1 is required for neuroblastoma tumorigenesis.". Oncogene. 2012. PMID 22266851.