ITPKA

ITPKA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1W2C, 1W2D, 1W2F, 4UPU
Dynodwyr
Cyfenwau	ITPKA, IP3-3KA, IP3KA, inositol-trisphosphate 3-kinase A
Dynodwyr allanol	OMIM: 147521 HomoloGene: 1671 GeneCards: ITPKA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calmodulin-dependent protein kinase activity • transferase activity • nucleotide binding • inositol-1,4,5-trisphosphate 3-kinase activity • ATP binding • calmodulin binding • kinase activity Cydrannau o'r gell • cytosol • dendritic spine Prosesau biolegol • dendritic spine maintenance • protein phosphorylation • inositol phosphate metabolic process • positive regulation of dendritic spine morphogenesis • actin cytoskeleton organization • inositol metabolic process • phosphorylation • GO:0072468 signal transduction • regulation of synaptic plasticity • inositol phosphate biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3706	n/a
Ensembl	ENSG00000137825	n/a
UniProt	P23677	n/a
RefSeq (mRNA)	NM_002220	n/a
RefSeq (protein)	NP_002211	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITPKA yw ITPKA a elwir hefyd yn Inositol-trisphosphate 3-kinase A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q15.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITPKA.

• IP3KA
• IP3-3KA

Llyfryddiaeth

• "ITPKA expression is a novel prognostic factor in hepatocellular carcinoma. ". Diagn Pathol. 2015. PMID 26249031.
• "A new calmodulin-binding motif for inositol 1,4,5-trisphosphate 3-kinase regulation. ". Biochem J. 2014. PMID 25101901.
• "Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells. ". Int J Cancer. 2011. PMID 21792881.
• "Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism. ". Biochem J. 2008. PMID 18498254.
• "Down-regulation of 1D-myo-inositol 1,4,5-trisphosphate 3-kinase A protein expression in oral squamous cell carcinoma.". Int J Oncol. 2006. PMID 16525636.