ITPK1

ITPK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2Q7D, 2ODT, 2QB5
Dynodwyr
Cyfenwau	ITPK1, ITRPK1, inositol-tetrakisphosphate 1-kinase
Dynodwyr allanol	OMIM: 601838 HomoloGene: 8588 GeneCards: ITPK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • isomerase activity • metal ion binding • kinase activity • inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity • catalytic activity • inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity • inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity • inositol-3,4,6-trisphosphate 1-kinase activity • ATP binding • hydrolase activity • magnesium ion binding • inositol-1,3,4-trisphosphate 6-kinase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity • inositol-1,3,4-trisphosphate 5-kinase activity • inositol tetrakisphosphate 1-kinase activity • inositol tetrakisphosphate 6-kinase activity Cydrannau o'r gell • cytosol • intracellular anatomical structure • apical plasma membrane • cytoplasm Prosesau biolegol • phosphorylation • blood coagulation • inositol phosphate metabolic process • inositol trisphosphate metabolic process • neural tube development • GO:0072468 signal transduction • GO:0098501, GO:0098502, GO:0006286 dephosphorylation • GO:0060554, GO:0060555 necroptosis • inositol phosphorylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3705	n/a
Ensembl	ENSG00000100605 ENSG00000274958	n/a
UniProt	Q13572	n/a
RefSeq (mRNA)	NM_014216 NM_001142593 NM_001142594 NM_001363707	n/a
RefSeq (protein)	NP_001136065 NP_001136066 NP_055031 NP_001350636	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITPK1 yw ITPK1 a elwir hefyd yn Inositol-tetrakisphosphate 1-kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q32.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITPK1.

• ITRPK1

Llyfryddiaeth

• "The maternal ITPK1 gene polymorphism is associated with neural tube defects in a high-risk Chinese population. ". PLoS One. 2014. PMID 24465924.
• "Regulation of inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) by reversible lysine acetylation. ". Proc Natl Acad Sci U S A. 2012. PMID 22308441.
• "Integration of inositol phosphate signaling pathways via human ITPK1. ". J Biol Chem. 2007. PMID 17616525.
• "Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. ". Mol Cell. 2005. PMID 15837423.
• "The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase.". Biochem J. 2005. PMID 15762844.