ITGB1

ITGB1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4WK4, 3G9W, 3T9K, 3VI3, 3VI4, 4DX9, 4WJK, 4WK0, 4WK2
Dynodwyr
Cyfenwau	ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1
Dynodwyr allanol	OMIM: 135630 HomoloGene: 22999 GeneCards: ITGB1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• virus receptor activity; • metal ion binding; • integrin binding; • GO:0001948, GO:0016582 protein binding; • laminin binding; • cell adhesion molecule binding; • collagen binding involved in cell-matrix adhesion; • coreceptor activity; • protease binding; • fibronectin binding; • actin binding; • C-X3-C chemokine binding; • protein heterodimerization activity; • GO:0032403 protein-containing complex binding; • cadherin binding; • signaling receptor activity;
Cydrannau o'r gell	• cytoplasm; • endosome; • bilen; • melanosome; • ruffle; • integrin alpha8-beta1 complex; • synapse; • ruffle membrane; • integrin complex; • perinuclear region of cytoplasm; • cell projection; • dendritic spine; • cell surface; • cleavage furrow; • integrin alpha7-beta1 complex; • extracellular exosome; • lamellipodium; • integral component of membrane; • recycling endosome; • integrin alpha1-beta1 complex; • intercalated disc; • filopodium; • neuromuscular junction; • receptor complex; • Cellbilen; • integrin alpha11-beta1 complex; • myelin sheath abaxonal region; • synaptic membrane; • integrin alpha10-beta1 complex; • cell junction; • integrin alpha2-beta1 complex; • sarcolemma; • external side of plasma membrane; • GO:0016023 cytoplasmic vesicle; • integrin alpha3-beta1 complex; • membrane raft; • focal adhesion; • glial cell projection; • Schaffer collateral - CA1 synapse; • glutamatergic synapse; • integral component of synaptic membrane; • GO:0009327 protein-containing complex;
Prosesau biolegol	• leukocyte cell-cell adhesion; • cell migration involved in sprouting angiogenesis; • stress fiber assembly; • viral entry into host cell; • B cell differentiation; • neuron projection development; • transforming growth factor beta receptor signaling pathway; • regulation of collagen catabolic process; • negative regulation of cell differentiation; • cardiac muscle cell differentiation; • cellular response to low-density lipoprotein particle stimulus; • in utero embryonic development; • cell-substrate adhesion; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • regulation of immune response; • GO:0022415 viral process; • dendrite morphogenesis; • cell fate specification; • G1 phase; • heterotypic cell-cell adhesion; • extracellular matrix organization; • cell-cell adhesion mediated by integrin; • cellular defense response; • cell adhesion; • formation of radial glial scaffolds; • axon extension; • leukocyte tethering or rolling; • integrin-mediated signaling pathway; • cell-matrix adhesion; • sarcomere organization; • negative regulation of anoikis; • leukocyte migration; • homophilic cell adhesion via plasma membrane adhesion molecules; • visual learning; • calcium-independent cell-matrix adhesion; • cardiac muscle tissue development; • negative regulation of Rho protein signal transduction; • receptor internalization; • regulation of cell cycle; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • mesodermal cell differentiation; • cell migration; • germ cell migration; • cell adhesion mediated by integrin; • basement membrane organization; • positive regulation of protein localization to plasma membrane; • G1/S transition of mitotic cell cycle; • ffagocytosis; • cytokine-mediated signaling pathway; • cell projection organization; • lamellipodium assembly; • positive regulation of angiogenesis; • modulation of chemical synaptic transmission; • positive regulation of protein kinase B signaling; • positive regulation of signaling receptor activity; • positive regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologau
	3688
	n/a
	ENSG00000150093
	n/a
	P05556
	n/a
NM_002211; NM_033666; NM_033667; NM_033668; NM_033669;
	NM_133376
	n/a
	NP_002202; NP_391988; NP_596867
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGB1 yw ITGB1 a elwir hefyd yn Integrin beta-1 ac Integrin subunit beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p11.22.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGB1.

CD29
FNRB
MDF2
VLAB
GPIIA
MSK12
VLA-BETA

Llyfryddiaeth[golygu | golygu cod]

"Novel ecto-tagged integrins reveal their trafficking in live cells. ". Nat Commun. 2017. PMID 28924207.
"β1 integrin signaling in asymmetric migration of keratinocytes under mechanical stretch in a co-cultured wound repair model. ". Biomed Eng Online. 2016. PMID 28155694.
"β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer. ". Int J Mol Sci. 2016. PMID 27589736.
"Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation. ". FASEB J. 2016. PMID 27565712.
"Integrinβ1 modulates tumour resistance to gemcitabine and serves as an independent prognostic factor in pancreatic adenocarcinomas.". Tumour Biol. 2016. PMID 27289231.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] ITGB1 - Cronfa NCBI

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[2]