ITGAL

ITGAL
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4IXD, 1CQP, 1DGQ, 1LFA, 1MJN, 1MQ8, 1MQ9, 1MQA, 1RD4, 1T0P, 1XDD, 1XDG, 1XUO, 1ZON, 1ZOO, 1ZOP, 2ICA, 2K8O, 2M3E, 2O7N, 3BN3, 3BQM, 3BQN, 3E2M, 3EOA, 3EOB, 3F74, 3F78, 3HI6, 3M6F, 3TCX, 5E6S, 5E6R, 5E6U
Dynodwyr
Cyfenwau	ITGAL, CD11A, LFA-1, LFA1A, integrin subunit alpha L
Dynodwyr allanol	OMIM: 153370 HomoloGene: 1666 GeneCards: ITGAL
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0032403 protein-containing complex binding • metal ion binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • ICAM-3 receptor activity • cell adhesion molecule binding Cydrannau o'r gell • integral component of membrane • integrin alphaL-beta2 complex • bilen • cell surface • integrin complex • extracellular exosome • Cellbilen • specific granule membrane Prosesau biolegol • leukocyte cell-cell adhesion • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell • extracellular matrix organization • receptor clustering • cell adhesion • regulation of immune response • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • leukocyte migration • GO:0072468 signal transduction • ffagocytosis • neutrophil degranulation • cell-cell adhesion Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3683	n/a
Ensembl	ENSG00000005844	n/a
UniProt	P20701	n/a
RefSeq (mRNA)	NM_001114380 NM_002209	n/a
RefSeq (protein)	NP_001107852 NP_002200	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ITGAL yw ITGAL a elwir hefyd yn Integrin alpha-L ac Integrin subunit alpha L (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 16, band 16p11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ITGAL.

• CD11A
• LFA-1
• LFA1A

Llyfryddiaeth

• "Expression of CD11a in lymphocyte subpopulation in immune thrombocytopenia. ". Int J Clin Exp Pathol. 2015. PMID 26884833.
• "FRET detection of lymphocyte function-associated antigen-1 conformational extension. ". Mol Biol Cell. 2015. PMID 25378583.
• "NMR characterization of the conformational fluctuations of the human lymphocyte function-associated antigen-1 I-domain. ". Protein Sci. 2014. PMID 25147050.
• "Blast cell deficiency of CD11a as a marker of acute megakaryoblastic leukemia and transient myeloproliferative disease in children with and without Down syndrome. ". Cytometry B Clin Cytom. 2013. PMID 23450818.
• "Suppression of LFA-1 expression by spermine is associated with enhanced methylation of ITGAL, the LFA-1 promoter area.". PLoS One. 2013. PMID 23418509.