ISL1 Dynodwyr Cyfenwau ISL1 Dynodwyr allanol OMIM: 600366 HomoloGene: 1661 GeneCards: ISL1 Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001105 transcription coactivator activity • sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • chromatin binding • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • bHLH transcription factor binding • GO:0001948, GO:0016582 protein binding • nuclear receptor binding • GO:0001158 cis-regulatory region sequence-specific DNA binding • estrogen receptor binding • promoter-specific chromatin binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • peripheral nervous system neuron development • positive regulation of interleukin-1 alpha production • pituitary gland development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of neuron differentiation • positive regulation of interleukin-12 production • axon regeneration • spinal cord motor neuron cell fate specification • trigeminal nerve development • neuron fate specification • outflow tract morphogenesis • positive regulation of interferon-gamma production • positive regulation of granulocyte colony-stimulating factor production • heart morphogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription by RNA polymerase II • positive regulation of angiogenesis • positive regulation of histone acetylation • outflow tract septum morphogenesis • endocardial cushion morphogenesis • ventricular cardiac muscle tissue morphogenesis • atrial septum morphogenesis • multicellular organism development • cardiac cell fate determination • regulation of secondary heart field cardioblast proliferation • cardiac muscle cell myoblast differentiation • cellular response to glucocorticoid stimulus • visceral motor neuron differentiation • mesenchymal cell differentiation • positive regulation of granulocyte macrophage colony-stimulating factor production • neural crest cell migration • neuron differentiation • positive regulation of cell population proliferation • positive regulation of interleukin-1 beta production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • regulation of gene expression • pancreas development • positive regulation of macrophage colony-stimulating factor production • positive regulation of vascular endothelial growth factor production • negative regulation of protein homodimerization activity • positive regulation of DNA binding • peripheral nervous system neuron axonogenesis • spinal cord motor neuron differentiation • neuron fate commitment • secondary heart field specification • innervation • negative regulation of intracellular estrogen receptor signaling pathway • negative regulation of inflammatory response • cardiac right ventricle morphogenesis • negative regulation of canonical Wnt signaling pathway • positive regulation of insulin secretion • sensory system development • pharyngeal system development • retinal ganglion cell axon guidance • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of cell differentiation • transcription, DNA-templated • cell differentiation • positive regulation of tyrosine phosphorylation of STAT protein • positive regulation of epithelial to mesenchymal transition • negative regulation of epithelial cell proliferation • heart development • axonogenesis Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn ISL1 yw ISL1 a elwir hefyd yn ISL LIM homeobox 1 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q11.1.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ISL1.
"An abnormally high expression of ISL-1 represents a potential prognostic factor in gastric cancer. ". Hum Pathol . 2015. PMID 26142548 . "[In Process Citation]. ". Aktuelle Urol . 2015. PMID 26077299 . "Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy. ". PLoS Genet . 2015. PMID 25763902 . "A positive feedback regulation of ISL-1 in DLBCL but not in pancreatic β-cells. ". Biochem Biophys Res Commun . 2014. PMID 24845569 . "Expression of the LIM homeobox domain transcription factor ISL1 (Islet-1) is frequent in rhabdomyosarcoma but very limited in other soft tissue sarcoma types. ". Pathology . 2014. PMID 24751901 . 
