IRS2

IRS2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3FQW, 3FQX
Dynodwyr
Cyfenwau	IRS2, IRS-2, insulin receptor substrate 2
Dynodwyr allanol	OMIM: 600797 HomoloGene: 2778 GeneCards: IRS2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin receptor binding • 14-3-3 protein binding • phosphatidylinositol 3-kinase binding • GO:0001948, GO:0016582 protein binding • protein kinase binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • signal transducer activity • protein phosphatase binding • protein domain specific binding Cydrannau o'r gell • cytoplasm • cytosol • Cellbilen • GO:0009327 protein-containing complex Prosesau biolegol • positive regulation of fatty acid beta-oxidation • positive regulation of glucose import • positive regulation of glycogen biosynthetic process • cellular response to peptide • positive regulation of cell migration • positive regulation of glucose metabolic process • response to glucose • MAPK cascade • mammary gland development • regulation of lipid metabolic process • negative regulation of long-chain fatty acid import across plasma membrane • brain development • positive regulation of mesenchymal cell proliferation • positive regulation of B cell proliferation • positive regulation of cell population proliferation • lipid homeostasis • glucose metabolic process • cellular response to insulin stimulus • negative regulation of B cell apoptotic process • cell population proliferation • phosphatidylinositol-mediated signaling • cellular response to glucose stimulus • GO:0072468 signal transduction • positive regulation of insulin secretion • negative regulation of kinase activity • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphate biosynthetic process • GO:1901047 insulin receptor signaling pathway • axon guidance • interleukin-7-mediated signaling pathway • positive regulation of protein kinase B signaling • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of Ras protein signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8660	n/a
Ensembl	ENSG00000185950	n/a
UniProt	Q9Y4H2	n/a
RefSeq (mRNA)	NM_003749	n/a
RefSeq (protein)	NP_003740	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IRS2 yw IRS2 a elwir hefyd yn Insulin receptor substrate 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 13, band 13q34.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IRS2.

• IRS-2

Llyfryddiaeth

• "The G1057D polymorphism of insulin receptor substrate-2 associated with gestational diabetes mellitus. ". Gynecol Endocrinol. 2014. PMID 24401133.
• "A polymorphism (rs4773092, Cys816Cys) of IRS2 affects auditory hallucinations in schizophrenia patients. ". Psychiatry Res. 2013. PMID 23706954.
• "FSH stimulates IRS-2 expression in human granulosa cells through cAMP/SP1, an inoperative FSH action in PCOS patients. ". Cell Signal. 2015. PMID 26388164.
• "Association of the G1057D polymorphism in insulin receptor substrate 2 gene with type 2 diabetes mellitus: a meta-analysis. ". J Diabetes Complications. 2015. PMID 25959789.
• "Lack of association between insulin receptor substrate2 rs1805097 polymorphism and the risk of colorectal and breast cancer: a meta-analysis.". PLoS One. 2014. PMID 24497996.