IRS1

IRS1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IRS, 1K3A, 1QQG, 2Z8C
Dynodwyr
Cyfenwau	IRS1, HIRS-1, insulin receptor substrate 1
Dynodwyr allanol	OMIM: 147545 HomoloGene: 4049 GeneCards: IRS1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin-like growth factor receptor binding • transmembrane receptor protein tyrosine kinase adaptor activity • SH2 domain binding • signal transducer activity • phosphatidylinositol 3-kinase binding • GO:0001948, GO:0016582 protein binding • protein kinase C binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphotyrosine residue binding • insulin receptor binding Cydrannau o'r gell • cytoplasm • intracellular membrane-bounded organelle • caveola • insulin receptor complex • cnewyllyn cell • cytosol • Cellbilen Prosesau biolegol • positive regulation of fatty acid beta-oxidation • positive regulation of glucose import • insulin-like growth factor receptor signaling pathway • negative regulation of insulin secretion • positive regulation of glycogen biosynthetic process • glucose homeostasis • response to peptide hormone • positive regulation of glucose metabolic process • MAPK cascade • positive regulation of phosphatidylinositol 3-kinase activity • response to insulin • GO:1903105 negative regulation of insulin receptor signaling pathway • positive regulation of cell population proliferation • cellular response to insulin stimulus • phosphatidylinositol 3-kinase signaling • GO:1903106 positive regulation of insulin receptor signaling pathway • phosphatidylinositol-mediated signaling • GO:0072468 signal transduction • GO:1901047 insulin receptor signaling pathway • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • interleukin-7-mediated signaling pathway • positive regulation of protein kinase B signaling • cellular response to fatty acid Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3667	n/a
Ensembl	ENSG00000169047	n/a
UniProt	P35568	n/a
RefSeq (mRNA)	NM_005544	n/a
RefSeq (protein)	NP_005535	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IRS1 yw IRS1 a elwir hefyd yn Insulin receptor substrate 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q36.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IRS1.

• HIRS-1

Llyfryddiaeth

• "Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors. ". Biochim Biophys Acta. 2017. PMID 28011403.
• "Genetic variation near IRS1 is associated with adiposity and a favorable metabolic profile in U.S. Hispanics/Latinos. ". Obesity (Silver Spring). 2016. PMID 27663718.
• "Association between IRS1 Gene Polymorphism and Autism Spectrum Disorder: A Pilot Case-Control Study in Korean Males. ". Int J Mol Sci. 2016. PMID 27483248.
• "Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus. ". Cardiovasc Diabetol. 2016. PMID 27005817.
• "Lack of association between the insulin receptor substrates-1 Gly972Arg polymorphism and type-2 diabetes mellitus among Saudis from Eastern Saudi Arabia.". Saudi Med J. 2015. PMID 26620983.