IQGAP1

IQGAP1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1X0H, 2RR8, 3FAY, 3I6X
Dynodwyr
Cyfenwau	IQGAP1, HUMORFA01, SAR1, p195, IQ motif containing GTPase activating protein 1
Dynodwyr allanol	OMIM: 603379 HomoloGene: 74514 GeneCards: IQGAP1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • calcium ion binding • S100 protein binding • protein domain specific binding • GO:0032403 protein-containing complex binding • protein serine/threonine kinase activator activity • GTPase inhibitor activity • GO:0001948, GO:0016582 protein binding • protein phosphatase binding • protein kinase binding • phosphatidylinositol-3,4,5-trisphosphate binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • mitogen-activated protein kinase binding • cadherin binding • calmodulin binding • small GTPase binding • GO:0032947 molecular adaptor activity Cydrannau o'r gell • cytoplasm • cytosol • lateral plasma membrane • cell-cell junction • bilen • microtubule cytoskeleton • growth cone • ruffle • extrinsic component of cytoplasmic side of plasma membrane • Cellbilen • slit diaphragm • axon • midbody • cell leading edge • Microffilament • actin cytoskeleton • neuron projection • cytoplasmic ribonucleoprotein granule • microtubule • extracellular exosome • membrane raft • cnewyllyn cell • focal adhesion • secretory granule membrane • GO:0009327 protein-containing complex • ribonucleoprotein complex Prosesau biolegol • cellular response to calcium ion • glomerular visceral epithelial cell development • epidermal growth factor receptor signaling pathway • negative regulation of dephosphorylation • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity • cellular response to platelet-derived growth factor stimulus • cellular response to fibroblast growth factor stimulus • neuron projection extension • cellular response to epidermal growth factor stimulus • GO:0032657 regulation of cytokine production • fibroblast growth factor receptor signaling pathway • platelet-derived growth factor receptor signaling pathway • GO:0072468 signal transduction • positive regulation of protein kinase activity • positive regulation of focal adhesion assembly • positive regulation of peptidyl-tyrosine autophosphorylation • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of protein localization • positive regulation of dendrite development • positive regulation of MAP kinase activity • positive regulation of vascular associated smooth muscle cell migration • GO:0034259 negative regulation of GTPase activity • response to angiotensin • neutrophil degranulation • regulation of mitotic cell cycle • cell migration • GO:0022415 viral process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8826	n/a
Ensembl	ENSG00000140575	n/a
UniProt	P46940	n/a
RefSeq (mRNA)	NM_003870	n/a
RefSeq (protein)	NP_003861	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IQGAP1 yw IQGAP1 a elwir hefyd yn Ras GTPase-activating-like protein IQGAP1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IQGAP1.

• SAR1
• p195
• HUMORFA01

Llyfryddiaeth

• "IQGAP1‑siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines. ". Mol Med Rep. 2017. PMID 28259970.
• "IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status. ". Int J Mol Sci. 2017. PMID 28098764.
• "SUMOylation of IQGAP1 promotes the development of colorectal cancer. ". Cancer Lett. 2017. PMID 28987385.
• "The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production. ". J Immunol. 2017. PMID 28864474.
• "IQ-domain GTPase-activating protein 1 promotes the malignant phenotype of invasive ductal breast carcinoma via canonical Wnt pathway.". Tumour Biol. 2017. PMID 28618949.