INPPL1

INPPL1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2K4P, 2KSO, 2MK2, 3NR8, 4A9C
Dynodwyr
Cyfenwau	INPPL1, OPSMD, SHIP2, inositol polyphosphate phosphatase like 1
Dynodwyr allanol	OMIM: 600829 HomoloGene: 1204 GeneCards: INPPL1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • SH3 domain binding • SH2 domain binding • GO:0001948, GO:0016582 protein binding • actin binding • hydrolase activity • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cydrannau o'r gell • Golgi apparatus • cell projection • bilen • filopodium • Cellbilen • Cytosgerbwd • lamellipodium • cytoplasm • cytosol Prosesau biolegol • endocytosis • cellular lipid metabolic process • actin filament organization • immune system process • inositol phosphate metabolic process • endochondral ossification • post-embryonic development • negative regulation of gene expression • response to insulin • cell adhesion • phosphatidylinositol dephosphorylation • glucose metabolic process • phosphatidylinositol biosynthetic process • ruffle assembly • negative regulation of cell population proliferation • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3636	n/a
Ensembl	ENSG00000165458	n/a
UniProt	O15357	n/a
RefSeq (mRNA)	NM_001567	n/a
RefSeq (protein)	NP_001558	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn INPPL1 yw INPPL1 a elwir hefyd yn Inositol polyphosphate phosphatase like 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.4.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn INPPL1.

• OPSMD
• SHIP2

Llyfryddiaeth

• "INPPL1 gene mutations in opsismodysplasia. ". J Hum Genet. 2017. PMID 27708270.
• "Expression, Purification, Crystallisation and X-ray Crystallographic Analysis of a Truncated Form of Human Src Homology 2 Containing Inositol 5-Phosphatase 2. ". Protein J. 2016. PMID 27170292.
• "Dissociation of a Dynamic Protein Complex Studied by All-Atom Molecular Simulations. ". Biophys J. 2016. PMID 26910424.
• "SHIP2 controls plasma membrane PI(4,5)P2 thereby participating in the control of cell migration in 1321 N1 glioblastoma cells. ". J Cell Sci. 2016. PMID 26826186.
• "SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.". Free Radic Biol Med. 2015. PMID 26456051.