INHBA

INHBA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NYS, 1NYU, 1S4Y, 2ARP, 2ARV, 2B0U, 2P6A, 3B4V, 4MID, 5HLY, 5HLZ
Dynodwyr
Cyfenwau	INHBA, EDF, FRP, inhibin beta A, inhibin beta A subunit, inhibin subunit beta A
Dynodwyr allanol	OMIM: 147290 HomoloGene: 1653 GeneCards: INHBA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transforming growth factor beta receptor binding • signaling receptor binding • hormone activity • identical protein binding • growth factor activity • cytokine activity • protein heterodimerization activity • type II activin receptor binding • peptide hormone binding • GO:0001948, GO:0016582 protein binding • inhibin binding Cydrannau o'r gell • inhibin A complex • activin A complex • perinuclear region of cytoplasm • extracellular region • extracellular space Prosesau biolegol • negative regulation of cell population proliferation • eyelid development in camera-type eye • endodermal cell differentiation • negative regulation of follicle-stimulating hormone secretion • GABAergic neuron differentiation • cell-cell signaling • progesterone secretion • mesodermal cell differentiation • negative regulation of macrophage differentiation • odontogenesis • hair follicle development • hematopoietic progenitor cell differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of phosphorylation • SMAD protein signal transduction • extrinsic apoptotic signaling pathway • positive regulation of follicle-stimulating hormone secretion • cell surface receptor signaling pathway • positive regulation of pathway-restricted SMAD protein phosphorylation • nervous system development • positive regulation of ovulation • GO:1901313 positive regulation of gene expression • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • cellular response to cholesterol • mesoderm formation • activin receptor signaling pathway • negative regulation of B cell differentiation • ovarian follicle development • striatal medium spiny neuron differentiation • GO:0051247, GO:0051200 positive regulation of protein metabolic process • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • hemoglobin biosynthetic process • roof of mouth development • positive regulation of erythrocyte differentiation • cellular response to follicle-stimulating hormone stimulus • regulation of MAPK cascade • cell development • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell cycle • negative regulation of cell growth • cell differentiation • defense response • erythrocyte differentiation • male gonad development • regulation of follicle-stimulating hormone secretion • regulation of signaling receptor activity • G1/S transition of mitotic cell cycle • response to wounding • regulation of apoptotic process • negative regulation of hair follicle development • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3624	n/a
Ensembl	ENSG00000122641	n/a
UniProt	P08476	n/a
RefSeq (mRNA)	NM_002192	n/a
RefSeq (protein)	NP_002183 NP_002183.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn INHBA yw INHBA a elwir hefyd yn Inhibin beta A subunit ac Inhibin, beta A (Activin A, activin AB alpha polypeptide) (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn INHBA.

• EDF
• FRP

Llyfryddiaeth

• "Paracrine Activin-A Signaling Promotes Melanoma Growth and Metastasis through Immune Evasion. ". J Invest Dermatol. 2017. PMID 28844941.
• "Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages. ". EMBO Mol Med. 2017. PMID 27932444.
• "Activin A programs the differentiation of human TFH cells. ". Nat Immunol. 2016. PMID 27376469.
• "Human eosinophil activin A synthesis and mRNA stabilization are induced by the combination of IL-3 plus TNF. ". Immunol Cell Biol. 2016. PMID 27001469.
• "Activin a signaling regulates cell invasion and proliferation in esophageal adenocarcinoma.". Oncotarget. 2015. PMID 26447543.