ILK

ILK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4HI9, 2KBX, 3F6Q, 3IXE, 3KMU, 3KMW, 3REP, 4HI8
Dynodwyr
Cyfenwau	ILK, HEL-S-28, ILK-1, ILK-2, P59, p59integrin linked kinase
Dynodwyr allanol	OMIM: 602366 HomoloGene: 3318 GeneCards: ILK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • SH3 domain binding • kinase activity • integrin binding • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • ATP binding • protein kinase binding • signal transducer activity Cydrannau o'r gell • cell projection • bilen • cell-cell junction • Cellbilen • sarcomere • nucleoplasm • dendritic shaft • cell junction • neuronal cell body • terminal bouton • axon • costamere • lamellipodium • stress fiber • cytoplasm • cytosol • focal adhesion Prosesau biolegol • fibroblast migration • GO:1904089 negative regulation of neuron apoptotic process • negative regulation of smooth muscle cell proliferation • neuron projection morphogenesis • positive regulation of protein kinase B signaling • regulation of actin cytoskeleton organization • positive regulation of MAP kinase activity • protein kinase B signaling • protein heterooligomerization • negative regulation of protein kinase activity • phosphorylation • myelin assembly • positive regulation of cell-matrix adhesion • positive regulation of cell migration • positive regulation of canonical Wnt signaling pathway • Schwann cell development • negative regulation of neural precursor cell proliferation • outflow tract morphogenesis • negative regulation of smooth muscle cell migration • negative regulation of apoptotic process • myelination in peripheral nervous system • positive regulation of axonogenesis • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • protein phosphorylation • negative regulation of cardiac muscle cell apoptotic process • branching involved in ureteric bud morphogenesis • positive regulation of osteoblast differentiation • positive regulation of dendrite morphogenesis • cell projection organization • positive regulation of myoblast differentiation • GO:0035404 peptidyl-serine phosphorylation • establishment or maintenance of epithelial cell apical/basal polarity • regulation of cell growth • positive regulation of cell population proliferation • positive regulation of BMP signaling pathway • integrin-mediated signaling pathway • substrate adhesion-dependent cell spreading • positive regulation of phosphorylation • cell-matrix adhesion • cell population proliferation • positive regulation of axon extension • platelet aggregation • nerve development • positive regulation of MAPK cascade • cell junction assembly • MAPK cascade • multicellular organism development • supramolecular fiber organization • tumor necrosis factor-mediated signaling pathway • positive regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3611	n/a
Ensembl	ENSG00000166333	n/a
UniProt	Q13418	n/a
RefSeq (mRNA)	NM_001014794 NM_001014795 NM_001278441 NM_001278442 NM_004517	n/a
RefSeq (protein)	NP_001014794 NP_001014795 NP_001265370 NP_001265371 NP_004508	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ILK yw ILK a elwir hefyd yn Integrin linked kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11p15.4.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ILK.

• P59
• ILK-1
• ILK-2
• p59ILK
• HEL-S-28

Llyfryddiaeth

• "Emodin Inhibits Migration and Invasion of Human Endometrial Stromal Cells by Facilitating the Mesenchymal-Epithelial Transition Through Targeting ILK. ". Reprod Sci. 2016. PMID 27130230.
• "Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target. ". Surgery. 2016. PMID 26549818.
• "Overexpression of ILK promotes temozolomide resistance in glioma cells. ". Mol Med Rep. 2017. PMID 28138714.
• "Increased expression of integrin-linked kinase during decidualization regulates the morphological transformation of endometrial stromal cells. ". Fertil Steril. 2017. PMID 28069177.
• "Silencing of ILK attenuates the abnormal proliferation and migration of human Tenon's capsule fibroblasts induced by TGF-β2.". Int J Mol Med. 2016. PMID 27315599.