IL7R

IL7R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3DI2, 3DI3, 3UP1
Dynodwyr
Cyfenwau	IL7R, CD127, CDW127, IL-7R-alpha, IL7RA, ILRA, Interleukin-7 receptor-α, interleukin 7 receptor
Dynodwyr allanol	OMIM: 146661 HomoloGene: 1646 GeneCards: IL7R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0003823, GO:0051635 antigen binding • interleukin-7 receptor activity • GO:0001948, GO:0016582 protein binding • GO:0016518 cytokine receptor activity Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • extracellular region • external side of plasma membrane • clathrin-coated vesicle membrane Prosesau biolegol • regulation of cell size • regulation of DNA recombination • positive regulation of T cell differentiation in thymus • homeostasis of number of cells • negative regulation of T cell mediated cytotoxicity • cell surface receptor signaling pathway • B cell proliferation • T cell differentiation • GO:1901313 positive regulation of gene expression • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • GO:0000767 cell morphogenesis • lymph node development • immunoglobulin production • GO:0072468 signal transduction • interleukin-7-mediated signaling pathway • positive regulation of cell population proliferation • positive regulation of receptor signaling pathway via STAT • membrane organization • negative regulation of T cell apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3575	n/a
Ensembl	ENSG00000168685	n/a
UniProt	P16871	n/a
RefSeq (mRNA)	NM_002185	n/a
RefSeq (protein)	NP_002176	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL7R yw IL7R a elwir hefyd yn Interleukin-7 receptor subunit alpha ac Interleukin 7 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5p13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL7R.

• ILRA
• CD127
• IL7RA
• CDW127
• IL-7R-alpha

Llyfryddiaeth

• "Identification of Heterozygous Single- and Multi-exon Deletions in IL7R by Whole Exome Sequencing. ". J Clin Immunol. 2017. PMID 27807805.
• "Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity. ". Haematologica. 2016. PMID 27470599.
• "Interleukin 7 receptor polymorphisms and the risk of multiple sclerosis: A meta-analysis. ". Mult Scler Relat Disord. 2016. PMID 27456877.
• "Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment. ". Blood. 2016. PMID 27268088.
• "Association between the IL7R T244I polymorphism and multiple sclerosis risk: a meta analysis.". Neurol Sci. 2016. PMID 27188999.