IL36RN

IL36RN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4P0J, 4P0K, 4P0L
Dynodwyr
Cyfenwau	IL36RN, FIL1, FIL1(DELTA), FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, IL36RA, PSORP, IL-36Ra, PSORS14, interleukin 36 receptor antagonist
Dynodwyr allanol	OMIM: 605507 HomoloGene: 10453 GeneCards: IL36RN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • GO:0001948, GO:0016582 protein binding • interleukin-1 receptor binding • interleukin-1 receptor antagonist activity Cydrannau o'r gell • extracellular space • extracellular region Prosesau biolegol • negative regulation of interleukin-6 production • negative regulation of cytokine-mediated signaling pathway • innate immune response • negative regulation of interleukin-17 production • antifungal humoral response • immune system process • inflammatory response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of signaling receptor activity • cytokine-mediated signaling pathway • neutrophil chemotaxis • positive regulation of interleukin-6 production • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of JNK cascade • cellular response to lipopolysaccharide Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	26525	n/a
Ensembl	ENSG00000136695	n/a
UniProt	Q9UBH0	n/a
RefSeq (mRNA)	NM_173170 NM_012275	n/a
RefSeq (protein)	NP_036407 NP_775262	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL36RN yw IL36RN a elwir hefyd yn Interleukin 36 receptor antagonist (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL36RN.

• FIL1
• FIL1D
• IL1F5
• IL1L1
• PSORP
• IL1HY1
• IL1RP3
• IL36RA
• IL-36Ra
• PSORS14
• FIL1(DELTA)

Llyfryddiaeth

• "Association analysis of psoriasis vulgaris and psoriatic arthritis with loss-of-function mutations in IL36RN in German patients. ". Br J Dermatol. 2016. PMID 27038307.
• "Integrative genomic analysis of interleukin-36RN and its prognostic value in cancer. ". Mol Med Rep. 2016. PMID 26676204.
• "Mutations in IL36RN are associated with geographic tongue. ". Hum Genet. 2017. PMID 27900482.
• "Mutation analysis of IL36RN gene in Japanese patients with palmoplantar pustulosis. ". J Dermatol. 2017. PMID 27542682.
• "IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases.". J Invest Dermatol. 2016. PMID 27220475.