IL2

IL2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IRL, 1M47, 1M48, 1M49, 1M4A, 1M4B, 1M4C, 1NBP, 1PW6, 1PY2, 1QVN, 1Z92, 2B5I, 2ERJ, 3QAZ, 3QB1, 3INK, 4NEJ, 4NEM
Dynodwyr
Cyfenwau	IL2, IL-2, TCGF, lymphokine, interleukin 2
Dynodwyr allanol	OMIM: 147680 HomoloGene: 488 GeneCards: IL2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • interleukin-2 receptor binding • glycosphingolipid binding • kinase activator activity • growth factor activity • kappa-type opioid receptor binding • carbohydrate binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • intracellular anatomical structure • extracellular space Prosesau biolegol • positive regulation of T cell differentiation • GO:0033128 negative regulation of protein phosphorylation • G protein-coupled receptor signaling pathway • positive regulation of protein phosphorylation • positive regulation of inflammatory response • adaptive immune response • negative regulation of heart contraction • immune system process • positive regulation of cytosolic calcium ion concentration • positive regulation of regulatory T cell differentiation • cell-cell signaling • positive regulation of interferon-gamma production • natural killer cell activation • negative regulation of apoptotic process • positive regulation of dendritic spine development • negative regulation of lymphocyte proliferation • MAPK cascade • regulation of T cell homeostatic proliferation • T cell differentiation • positive regulation of cell growth • protein kinase C-activating G protein-coupled receptor signaling pathway • cell adhesion • positive regulation of B cell proliferation • positive regulation of tissue remodeling • positive regulation of T cell proliferation • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cell population proliferation • extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of B cell apoptotic process • positive regulation of isotype switching to IgG isotypes • positive regulation of interleukin-17 production • response to ethanol • negative regulation of inflammatory response • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of activated T cell proliferation • negative regulation of T-helper 17 cell differentiation • leukocyte activation involved in immune response • positive regulation of tyrosine phosphorylation of STAT protein • regulation of regulatory T cell differentiation • regulation of signaling receptor activity • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway • positive regulation of kinase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3558	n/a
Ensembl	ENSG00000109471	n/a
UniProt	P60568	n/a
RefSeq (mRNA)	NM_000586	n/a
RefSeq (protein)	NP_000577	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL2 yw IL2 a elwir hefyd yn Interleukin 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q27.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL2.

• IL-2
• TCGF
• lymphokine

Llyfryddiaeth

• "Ontak-like human IL-2 fusion toxin. ". J Immunol Methods. 2017. PMID 28551309.
• "Anticancer agent pristimerin inhibits IL-2 induced activation of T lymphocytes. ". J Exp Ther Oncol. 2016. PMID 28471123.
• "Lymphocytes incubated in the presence of IL-2 lose the capacity for chemotaxis but acquire antitumor activity. ". Dokl Biol Sci. 2017. PMID 28429264.
• "Adoptive immunotherapy with interleukin-2 & induced killer cells in non-small cell lung cancer: A systematic review & meta-analysis. ". Indian J Med Res. 2016. PMID 27748271.
• "IL-2 and polyoma BK virus infection; A systematic review article.". Cytokine. 2016. PMID 27718431.