IL18

IL18
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J0S, 2VXT, 3F62, 4EEE, 4EKX, 4HJJ, 3WO2, 3WO3, 3WO4, 4R6U, 4XFS, 4XFT, 4XFU
Dynodwyr
Cyfenwau	IL18, IGIF, IL-18, IL-1g, IL1F4, interleukin 18
Dynodwyr allanol	OMIM: 600953 HomoloGene: 1200 GeneCards: IL18
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • cytokine activity • interleukin-18 receptor binding Cydrannau o'r gell • cytosol • extracellular region • extracellular space Prosesau biolegol • positive regulation of inflammatory response • cell-cell signaling • GO:1904579 cellular response to organic cyclic compound • type 2 immune response • MAPK cascade • positive regulation of natural killer cell proliferation • Cwsg • regulation of cell adhesion • positive regulation of NK T cell proliferation • positive regulation of granulocyte macrophage colony-stimulating factor production • positive regulation of tissue remodeling • angiogenesis • T-helper 1 type immune response • positive regulation of interleukin-17 production • inflammatory response • lipopolysaccharide-mediated signaling pathway • positive regulation of activated T cell proliferation • positive regulation of protein kinase B signaling • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of smooth muscle cell proliferation • activation of protein kinase B activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of tyrosine phosphorylation of STAT protein • GO:1901313 positive regulation of gene expression • positive regulation of macrophage derived foam cell differentiation • natural killer cell activation • positive regulation of interferon-gamma production • cholesterol homeostasis • positive regulation of T-helper 2 cell differentiation • negative regulation of myoblast differentiation • triglyceride homeostasis • cell population proliferation • regulation of signaling receptor activity • interleukin-6 production • T-helper 1 cell cytokine production • neutrophil activation • natural killer cell mediated cytotoxicity • cytokine-mediated signaling pathway • interleukin-18-mediated signaling pathway • positive regulation of NIK/NF-kappaB signaling • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of NF-kappaB transcription factor activity • positive regulation of T-helper 1 cell cytokine production • positive regulation of cold-induced thermogenesis • positive regulation of neuroinflammatory response • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3606	n/a
Ensembl	ENSG00000150782	n/a
UniProt	Q14116	n/a
RefSeq (mRNA)	NM_001243211 NM_001562 NM_001386420	n/a
RefSeq (protein)	NP_001230140 NP_001553 NP_001230140.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL18 yw IL18 a elwir hefyd yn Interleukin 18 ac Interleukin 18 (Interferon-gamma-inducing factor), isoform CRA_a (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL18.

• IGIF
• IL-18
• IL-1g
• IL1F4

Llyfryddiaeth

• "Alteration of -656(G/T) and -607(C/A) polymorphisms in interleukin-18 (IL-18) gene in house dust mite-sensitive allergic rhinitis patients in Thailand. ". Genet Mol Res. 2017. PMID 28692122.
• "Genetic variants of interleukin-18 are associated with reduced risk of atrial fibrillation in a population from Northeast China. ". Gene. 2017. PMID 28526653.
• "Interleukin-18 activates Vγ9Vδ2+ T cells from HIV-positive individuals: recovering the response to phosphoantigen. ". Immunology. 2017. PMID 28342224.
• "Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections. ". Genes Immun. 2017. PMID 28300059.
• "Assessment of IL-18 Serum Level and Its Promoter Polymorphisms in the Saudi Coronary Artery Disease (CAD) Patients.". J Cell Biochem. 2017. PMID 28059484.