IKBKG

IKBKG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JVX, 2JVY, 3BRT, 3BRV, 3CL3, 3FX0, 4BWN, 5AAY
Dynodwyr
Cyfenwau	IKBKG, AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IMD33, IP, IP1, IP2, IPD2, NEMO, ZC2HC9, IKKAP1, IKKG, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, inhibitor of nuclear factor kappa B kinase subunit gamma, EDAID1, inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Dynodwyr allanol	OMIM: 300248 HomoloGene: 2698 GeneCards: IKBKG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • protein domain specific binding • signal transducer activity • metal ion binding • GO:0001948, GO:0016582 protein binding • linear polyubiquitin binding • ubiquitin protein ligase binding • identical protein binding • K63-linked polyubiquitin modification-dependent protein binding • peroxisome proliferator activated receptor binding • protein heterodimerization activity Cydrannau o'r gell • cytoplasm • spindle pole • ubiquitin ligase complex • intracellular anatomical structure • IkappaB kinase complex • mitotic spindle • cnewyllyn cell • cytosol • nucleoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • regulation of tumor necrosis factor-mediated signaling pathway • response to virus • stimulatory C-type lectin receptor signaling pathway • transcription, DNA-templated • TRIF-dependent toll-like receptor signaling pathway • Fc-epsilon receptor signaling pathway • JNK cascade • positive regulation of NF-kappaB transcription factor activity • stress-activated MAPK cascade • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response • inflammatory response • GO:0022415 viral process • I-kappaB kinase/NF-kappaB signaling • T cell receptor signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • establishment of vesicle localization • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of neuron death • GO:0097285 apoptotic process • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • cellular response to DNA damage stimulus • positive regulation of macroautophagy • protein deubiquitination • anoikis • MyD88-independent toll-like receptor signaling pathway • interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	8517	n/a
Ensembl	ENSG00000269335	n/a
UniProt	Q9Y6K9	n/a
RefSeq (mRNA)	NM_001099856 NM_001099857 NM_001145255 NM_003639 NM_001321396 NM_001321397 NM_001377312 NM_001377313 NM_001377314 NM_001377315	n/a
RefSeq (protein)	NP_001093326 NP_001093327 NP_001138727 NP_001308325 NP_001308326 NP_003630 NP_001364241 NP_001364242 NP_001364243 NP_001364244	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IKBKG yw IKBKG a elwir hefyd yn NF-kappa-B essential modulator ac Inhibitor of nuclear factor kappa B kinase subunit gamma (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xq28.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IKBKG.

• IP
• IP1
• IP2
• FIP3
• IKKG
• IPD2
• NEMO
• FIP-3
• Fip3p
• IMD33
• AMCBX1
• IKKAP1
• ZC2HC9
• IKK-gamma

Llyfryddiaeth

• "Hematopoietic stem cell transplantation in 29 patients hemizygous for hypomorphic IKBKG/NEMO mutations. ". Blood. 2017. PMID 28679735.
• "Binding Site Configurations Probe the Structure and Dynamics of the Zinc Finger of NEMO (NF-κB Essential Modulator). ". Biochemistry. 2017. PMID 28035815.
• "Incontinentia pigmenti in a father and daughter. ". Br J Dermatol. 2016. PMID 27037530.
• "The red edge excitation shift phenomenon can be used to unmask protein structural ensembles: implications for NEMO-ubiquitin interactions. ". FEBS J. 2016. PMID 27028374.
• "Incontinentia pigmenti (Bloch-Sulzberger syndrome).". Handb Clin Neurol. 2015. PMID 26564087.