IGF2

Igf2
Dynodwyr
Cyfenwau	insulin-like growth factor 2AL033362Igf-2Igf-IIM6prMprPeg2
Dynodwyr allanol	HomoloGene: 510 GeneCards: [1]
Lleoliad y genyn (bodau dynol)
Cr.	Chromosome 7 (human)
End	142,220,553 bp
Ontoleg y genyn
Gweithrediad moleciwlaidd	• hormone activity; • protein serine/threonine kinase activator activity; • GO:0001948, GO:0016582 protein binding; • growth factor activity; • receptor ligand activity; • insulin receptor binding; • insulin-like growth factor receptor binding; • integrin binding;
Cydrannau o'r gell	• extracellular region; • extracellular space; • collagen-containing extracellular matrix;
Prosesau biolegol	• exocrine pancreas development; • positive regulation of protein phosphorylation; • positive regulation of glycogen biosynthetic process; • ossification; • GO:0048554 positive regulation of catalytic activity; • osteoblast differentiation; • insulin receptor signaling pathway via phosphatidylinositol 3-kinase; • glucose metabolic process; • positive regulation of multicellular organism growth; • positive regulation of peptidyl-tyrosine phosphorylation; • animal organ morphogenesis; • positive regulation of glycogen (starch) synthase activity; • striated muscle cell differentiation; • positive regulation of cell division; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of protein serine/threonine kinase activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • in utero embryonic development; • embryonic placenta development; • GO:0033127, GO:2000281, GO:2000817 regulation of histone modification; • regulation of muscle cell differentiation; • embryonic placenta morphogenesis; • carbohydrate metabolic process; • regulation of signaling receptor activity; • positive regulation of activated T cell proliferation; • positive regulation of MAPK cascade; • positive regulation of mitotic nuclear division; • GO:1903106 positive regulation of insulin receptor signaling pathway; • positive regulation of protein kinase B signaling; • Cof; • positive regulation of cell population proliferation; • GO:1904578 response to organic cyclic compound; • response to nicotine; • positive regulation of blood vessel endothelial cell migration; • positive regulation of angiogenesis; • negative regulation of natural killer cell mediated cytotoxicity; • positive regulation of steroid hormone biosynthetic process; • positive regulation of vascular endothelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	16002
	n/a
	ENSMUSG00000048583
	n/a
	P09535
	P09535
	NM_001122736; NM_001122737; NM_010514; NM_001315488; NM_001315489
	n/a
	NP_001116208; NP_001116209; NP_001302417; NP_001302418; NP_034644
	NP_001116208; NP_001116209; NP_001302417; NP_001302418; NP_034644
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGF2 yw IGF2 a elwir hefyd yn Insulin like growth factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGF2.

GRDF
IGF-II
PP9974
C11orf43

Llyfryddiaeth

"A Loss-of-Function Splice Acceptor Variant in IGF2Is Protective for Type 2 Diabetes. ". Diabetes. 2017. PMID 28838971.
"Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19and 1-carbon metabolism. ". FASEB J. 2017. PMID 28778973.
"Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms. ". Oncogene. 2017. PMID 28534511.
"DNA methylation of imprinted loci of autosomal chromosomes and IGF2 is not affected in Parkinson's disease patients' peripheral blood mononuclear cells. ". Neurol Res. 2017. PMID 28081695.
"Allelic Characterization of IGF2 and H19 Gene Polymorphisms in Molar Tissues.". Asian Pac J Cancer Prev. 2016. PMID 27797252.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] IGF2 - Cronfa NCBI

[1]

[2]