IGF2

IGF2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3KR3, 1IGL, 2L29, 2V5P, 3E4Z
Dynodwyr
Cyfenwau	IGF2, C11orf43, GRDF, IGF-II, PP9974, insulin like growth factor 2, SRS3
Dynodwyr allanol	OMIM: 147470 HomoloGene: 510 GeneCards: IGF2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin receptor binding • hormone activity • GO:0001948, GO:0016582 protein binding • growth factor activity • insulin-like growth factor receptor binding • integrin binding • protein serine/threonine kinase activator activity • receptor ligand activity Cydrannau o'r gell • extracellular region • platelet alpha granule lumen • extracellular space Prosesau biolegol • regulation of gene expression by genetic imprinting • skeletal system development • GO:1901047 insulin receptor signaling pathway • positive regulation of protein kinase B signaling • GO:0009373 regulation of transcription, DNA-templated • ossification • platelet degranulation • multicellular organism development • glucose metabolic process • positive regulation of mitotic nuclear division • positive regulation of cell division • positive regulation of MAPK cascade • positive regulation of activated T cell proliferation • positive regulation of protein serine/threonine kinase activity • carbohydrate metabolic process • regulation of signaling receptor activity • GO:1901227 negative regulation of transcription by RNA polymerase II • osteoblast differentiation • in utero embryonic development • embryonic placenta development • positive regulation of protein phosphorylation • positive regulation of cell population proliferation • animal organ morphogenesis • exocrine pancreas development • GO:0033127, GO:2000281, GO:2000817 regulation of histone modification • insulin receptor signaling pathway via phosphatidylinositol 3-kinase • positive regulation of multicellular organism growth • GO:0048554 positive regulation of catalytic activity • positive regulation of glycogen biosynthetic process • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:1903106 positive regulation of insulin receptor signaling pathway • positive regulation of peptidyl-tyrosine phosphorylation • striated muscle cell differentiation • regulation of muscle cell differentiation • embryonic placenta morphogenesis • positive regulation of glycogen (starch) synthase activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3481	n/a
Ensembl	ENSG00000167244	n/a
UniProt	P01344	n/a
RefSeq (mRNA)	NM_001291862 NM_000612 NM_001007139 NM_001127598 NM_001291861	n/a
RefSeq (protein)	NP_000603 NP_001007140 NP_001121070 NP_001278790 NP_001278791	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGF2 yw IGF2 a elwir hefyd yn Insulin like growth factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGF2.

• GRDF
• IGF-II
• PP9974
• C11orf43

Llyfryddiaeth

• "A Loss-of-Function Splice Acceptor Variant in IGF2Is Protective for Type 2 Diabetes. ". Diabetes. 2017. PMID 28838971.
• "Impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19and 1-carbon metabolism. ". FASEB J. 2017. PMID 28778973.
• "Stromal-derived IGF2 promotes colon cancer progression via paracrine and autocrine mechanisms. ". Oncogene. 2017. PMID 28534511.
• "DNA methylation of imprinted loci of autosomal chromosomes and IGF2 is not affected in Parkinson's disease patients' peripheral blood mononuclear cells. ". Neurol Res. 2017. PMID 28081695.
• "Allelic Characterization of IGF2 and H19 Gene Polymorphisms in Molar Tissues.". Asian Pac J Cancer Prev. 2016. PMID 27797252.